| Description |
1 online resource (392 pages) |
| Contents |
Front Cover; Series Introduction; Preface; Contents; Contributors; 1. Introduction The Graft-Versus-Leukemia Effect; 2. The Immune Response to Alloantigens; 3. Experimental Animal Models in the Study of GVL Reactions; 4. Effector Cells and Mechanisms of the GVL Effect; 5. Minor Histocompatibility Antigens in GVL; 6. Tissue-Specific Antigens in GVL; 7. Oncoproteins as Tumor-Specific Antigens; 8. GVL Effects in Human Marrow Stem-Cell Transplants; 9. The GVL Effect in Donor Lymphocyte Transfusion; 10. The Graft-Versus-Myeloma Effect; 11. The Graft-Versus-Tumor Effect |
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12. Adoptive Allogeneic Cell-Mediated Immunotherapy and Nonmyeloablative Stem-Cell Transplantation13. Clinical and Basic Science Studies of Human Umbilical Cord Blood; Separating GVHD and GVL Reactions; T-Cell Subsets and Separation of GVL from GVHD; Molecular Immunological Modulation of Target Cells to Enhance the GVL Effect; Genetic Modulation of Effector Cells to Enhance GVL Effects; Leukemia-Reactive T Cells in Adoptive Immunotherapy for Relapsed Leukemia After Allogeneic Transplantation; The BCR-ABL Oncoprotein and Immunological Targeting; Back Cover |
| Summary |
This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic so |
| Notes |
Print version record |
| Subject |
Hematological oncology.
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Graft versus host disease.
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Hematopoietic stem cells -- Transplantation
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Graft vs Host Disease
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Graft versus host disease
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Hematological oncology
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Hematopoietic stem cells -- Transplantation
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| Form |
Electronic book
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| Author |
Jiang, Yin-Zhen
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| ISBN |
9781135548261 |
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1135548269 |
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