Title Applications of toxicogenomic technologies to predictive toxicology and risk assessment / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies

Published Washington, D.C. : National Academies Press, ©2007

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Description 1 online resource (xxii, 275 pages) : illustrations Contents Introduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations Summary The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways--an effort requiring funding, interagency coordination, and data management strategies Bibliography Includes bibliographical references (pages 213-254) Notes English Print version record Subject Genetic toxicology. DNA microarrays -- Statistical methods Health risk assessment. Carcinogenesis. Risk assessment. Toxicogenetics -- methods Health Status Indicators Oligonucleotide Array Sequence Analysis Hazardous Substances -- toxicity Risk Assessment Models, Statistical Carcinogenesis risk assessment. HEALTH & FITNESS -- Diseases -- Genetic. MEDICAL -- Genetics. Risk assessment Carcinogenesis DNA microarrays -- Statistical methods Genetic toxicology Health risk assessment Form Electronic book Author National Research Council (U.S.). Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology. ISBN 9780309112994 0309112990 1281109908 9781281109903 9786611109905 6611109900

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