| Description |
1 online resource (xxviii, 736 pages) |
| Contents |
Contents -- Contributors -- Preface -- Acknowledgements -- Abbreviations -- Color Plate Section -- Section I Mechanisms for Cardiac Hypertrophy -- 1. Mechanisms of Normal Cardiovascular Growth and Development -- 2. Cardiomyocyte Cell Cycle Control -- 3. Molecular Mechanisms of Cardiac Myocyte Death -- 4. Transcription Factors and Hypertrophy -- 5. G Protein-coupled Receptor Activation -- 6. Mechanotransduction in Cardiomyocyte Hypertrophy -- 7. Extracellular Matrix -- 8. Physiological Versus Pathological Cardiac Hypertrophy |
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9. Alterations in Signal Transduction10. Cell-based Therapies for Cardiac Regeneration and Repair -- 11. Oxidative Stress in the Regulation of Myocardial Hypertrophy and Failure -- Section II Mechanisms for Contractile Depression -- 12. Normal and Abnormal Excitation-contraction Coupling -- 13. Normal and Abnormal Calcium Homeostasis -- 14. Mechanisms of Reversible Ischemic Dysfunction -- 15. Cardiac Remodeling -- 16. The Role of Inflammatory Mediators in Cardiac Hypertrophy, Cardiac Remodeling and Myocardial Dysfunction |
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17. Control of Cardiac Function in Health and Disease by Mechanisms at the Level of the Sarcomere18. Cardiac Protein Folding and Degradation -- 19. The Cytoskeleton -- 20. Adrenergic Receptor Coupling and Uncoupling in Heart Failure -- 21. Environmental Factors in Cardiac Hypertrophy and Failure -- Section III Arrhythmogenesis -- 22. Cellular and Molecular Basis of Electrogenesis of Normal Cardiac Tissue -- 23. Abnormalities of Inward Currents Underlying Cardiac Depolarization: Role in Acquired and Heritable Arrhythmias -- 24. Repolarization Abnormalities |
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25. Cell-cell Communication Abnormalities26. Novel Targets for Arrhythmia Prevention or Treatment -- 27. Genetic Factors Underlying Susceptibility to Common Arrhythmias -- Section IV Genetic Basis for Cardiomyopathy -- 28. Epidemiology of Left Ventricular Hypertrophy and Dilated Cardiomyopathy -- 29. Left Ventricular Hypertrophy in Special Populations -- 30. Monogenic Causes of Cardiac Hypertrophy: Hypertrophic Cardiomyopathy and Related Phenotypes -- 31. Monogenic Dilated Cardiomyopathy -- 32. Cardiomyopathy in Muscular Dystrophies |
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33. Complex Cardiomyopathies: Laminopathies and Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy34. Mitochondrial Cardiomyopathies -- 35. Adregenic Receptor Polymorphisms in Heart Failure: Molecular and Physiological Phenotypes -- 36. Transcriptional Profiling in Heart Failure -- 37. Animal Models of Hypertrophic Cardiomyopathy: Relevance to Human Disease -- 38. Clinical Proteomics: Technologies to Define and Diagnose Heart Disease -- 39. Animal Models of Dilated Cardiomyopathy and Relevance to Human Disease |
| Summary |
Unique in its focus on this particular field of cardiovascular science, "Molecular Mechanisms of Cardiac Hypertrophy and Failure" reviews current knowledge of the mechanisms contributing to heart failure. Bringing together an internationally renowned team of contributors, the text provides expert reviews on the latest advances in molecular and cell biology, biochemistry and pharmacology.; Richly illustrated and suitable for a wide audience of clinicians and basic scientists in academia and industry, the book has particular emphasis on the following key areas: - cardiac hypertrophy - contractile depression - arrhythmogenesis - genetics - the clinical implications of the research in these areas.; With a broad, multi-disciplinary appeal, this important text will be of interest to clinical cardiologists, vascular medicine specialists, hematologists, and internists, as well as members of the cardiovascular research community and pharmaceutical and biotechnology industries |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Heart -- Hypertrophy -- Molecular aspects
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Cardiac arrest -- Molecular aspects
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Cardiomegaly -- physiopathology
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Heart Arrest -- physiopathology
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Heart -- growth & development
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Heart -- physiopathology
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Myocytes, Cardiac -- physiology
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HEALTH & FITNESS -- Diseases -- Heart.
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MEDICAL -- Cardiology.
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| Form |
Electronic book
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| Author |
Walsh, Richard A., 1946-
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| ISBN |
0203503244 |
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9780203503249 |
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