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Book Cover
Streaming video
Author Goldberg, Alfred (Harvard Medical School, USA), speaker

Title Protein degradation and defense against neurodegenerative disease : part 1 of 2 / Alfred Goldberg
Published London : Henry Stewart Talks, 2014
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (39 min.) : color, sound)
Series Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Protein homeostasis
Contents Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Brain -- Aging -- Molecular aspects.
Nervous system -- Degeneration.
Protein folding.
Proteins -- Metabolism.
Heat-Shock Proteins.
Lewy Bodies.
Neurodegenerative Diseases -- metabolism.
Proteasome Endopeptidase Complex.
Protein Folding.
Proteins -- chemistry.
Proteins -- metabolism.
Ubiquitin -- metabolism.
Genre/Form Video recordings.
Form Streaming video
Other Titles Protein degradation and defense against neurodegenerative disease, part 1 of 2