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Book Cover
E-book

Title Cell surface GRP78, a new paradigm in signal transduction biology / edited by Salvatore V. Pizzo
Published London, United Kingdom : Elsevier Ltd. : Academic Press, [2018]
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Description 1 online resource
Contents Front Cover; Cell Surface GRP78, a New Paradigm in Signal Transduction Biology; Copyright Page; Contents; List of Contributors; Preface; 1 An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology; Discovery of Cell Surface GRP78; GRP78 and Cancer Cell Biology; A Most Complex Signaling Mechanism; References; 2 The Endoplasmic Reticulum Chaperone GRP78 Also Functions as a Cell Surface Signaling Receptor; Introduction; Release of CS-GRP78 Into the Extracellular Environment; Secreted GRP78; GRP78 in Exosomes; Induction of GRP78 to the Cell Surface
3 Cell Surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in CancerIntroduction; Anchoring on the Cell Surface; Cell Surface Anchoring of ER-Transmembrane Chaperones; Cell Surface Anchoring of Peripheral Proteins; CS-GRP78 Binding Ligands, Membrane Proteins and Functions; Translocation Mechanisms; Intrinsic Factors; Protein-Protein Interaction in GRP78 Translocation; Trafficking Routes; Therapeutic Potential in Cancer; Antibodies; Peptide Conjugates; Proapoptotic Ligands; Conclusions and Perspectives; References
4 Cell Surface GRP78: A Novel Regulator of Tissue Factor Procoagulant ActivityThe 78 kDa Glucose-Regulated Protein (GRP78); GRP78 Protein Structure; Translocation of GRP78 to the Cell Surface; Regulating the Levels of Cell Surface GRP78; Nonchaperone Functions of GRP78; Ca2+ Binding Protein; GRP78 and Pathology; Anti-GRP78 Autoantibodies and Cancer; GRP78 and the Coagulation System; Tissue Factor; The Role of Tissue Factor in Hemostasis; Tissue Factor Structure; Tissue Factor and Disease; Regulation of Tissue Factor Activity; Tissue Factor Dimerization; Altered Phospholipid Asymmetry
CS-GRP78 Ligands and Their Cellular EffectsCS-GRP78 Forms Complexes With a Variety of Cell-Surface Anchored Proteins; CS-GRP78 Controls Key Oncogenic Signaling Pathways; Biological Functions of CS-GRP78 in Cancer; Cell Survival and Proliferation; Apoptosis; Invasion and Migration; Transcriptional Activation; Metabolism; The Role of CS-GRP78 in Other Physiological Diseases; Angiogenesis; Virus Internalization; Inflammation and Immunity; Arthritis; Therapeutic Targeting of CS-GRP78; GRP78 Autoantibodies and Their Physiological Roles; Concluding Remarks; References
Tissue Factor Compartmentalization in CaveolaeTissue Factor Disulfide Bond Isomerization; Regulation of Tissue Factor by Cell Surface GRP78; Implication of TF Activation via Cell Surface GRP78 in Cancer; Conclusion; References; 5 Novel Cell Surface Targets for the Plasminogen Activating System in the Brain: Implications for Human Disease; Introduction; The Voltage-Dependent Anion Channel 1; Functions of Voltage-Dependent Anion Channel; The Plasminogen Activator System in the Brain; GRP78 and VDAC in the Brain; The Voltage-Dependent Anion Channel and Beta-Amyloid Peptides
Analysis molecular chaperone GRP78
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed March 27, 2018)
Subject Cellular signal transduction.
Heat-Shock Proteins.
Signal Transduction.
Form Electronic book
Author Pizzo, Salvatore V., editor
ISBN 0128123524 (electronic bk.)
9780128123522 (electronic bk.)