pt. 1. Heat shock proteins and neurodegenerative diseases -- pt. 2. Heat shock proteins and neuroprotection -- pt. 3. Extracellular heat shock proteins and the nervous system -- pt. 4. Aging, control of life span and expression of heat shock proteins
Summary
With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis have been termed 'protein misfolding disorders' that are characterized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a therapeutic strategy to counter conformational changes in neural
