| Description |
1 online resource (xi, 213 pages) : illustrations |
| Contents |
880-01 Bach1: A heme-dependent transcriptional regulator in mammalian cellsBach1, like Hap1, binds to heme via HRMs; Heme affects Bach1 at three levels; Perspectives; References; Chapter 4 Heme-Regulated eIF2[alpha] Kinase in Translation and Erythropoiesis Jane-Jane Chen and Rajasekhar NVS Suragani; Overview; Introduction; HRI is responsible for heme-regulated translation in erythroid precursors; Phosphorylation of eIF2[alpha] under diverse cellular stresses by the family of eIF2[alpha] kinases; Activation of HRI by autophosphorylation; Inhibition of HRI activity by heme |
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880-01/(S Introduction / Li Zhang -- Heme biosynthesis and degradation : what happens when it goes haywire? / Li Zhang and Rebekah Sessoms -- Heme : an ingenious regulator of gene transcription / Li Zhang -- Heme-regulated eIF2α kinase in translation and erythropoiesis / Jane-Jane Chen and Rajasekhar NVS Suragani -- Role of heme in brain functions : Dr. Jekyll or Mr. Hyde? / Tatyana Chernova and Andrew G. Smith -- Heme and microRNA biogenesis / Feng Guo -- The vast potential of heme in regulating biological processes : a global perspective / Li Zhang [and others] -- The chemical and structural bases of heme recognition : binding interactions of heme with proteins and peptides / Y. Li and Li Zhang -- Clinical applications of heme biosynthetic pathway : photodynamic therapy with protoporphyrin IX / Huiying Ding, Baran D. Sumer and Jinming Gao |
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Preface; List of Contributors; Chapter 1 Introduction Li Zhang; Overview; References; Chapter 2 Heme Biosynthesis and Degradation: What Happens when it goes Haywire? Li Zhang and Rebekah Sessoms; Overview; Heme is synthesized by the actions of eight enzymes in humans; Heme biosynthesis is regulated according to the needs for heme in human cells; Defective heme biosynthesis causes serious diseases in humans; Heme is degraded continuously in the human body; Defects in heme degradation can cause serious diseases; References |
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Chapter 3 Heme: An Ingenious Regulator of Gene Transcription Li ZhangOverview; Heme can control the activity of diverse transcriptional regulators; Heme serves as a secondary messenger of oxygen in yeast; Heme can control the expression of a high number of genes in yeast; The heme activator protein Hap1 is a key regulator of gene transcription in response to fluctuations in oxygen and heme levels; Heme regulation of Hap1 transcription-activating activity requires the proper functioning of Hsp90 and Hsp70 molecular chaperones |
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Two distinct heme-binding domains in the cooperation of heme-regulation of HRITissue expression and phylogenetic conservation of HRI; Coordination of heme and globin synthesis by HRI; Regulation of erythroid differentiation by HRI; Integrated stress response of eIF2[alpha]P signaling; Concluding remarks; Acknowledgement; References; Chapter 5 Role of Heme in Brain Functions: Dr. Jekyll or Mr. Hyde? Tatyana Chernova and Andrew G. Smith; Overview; Heme synthesis and disturbances pertinent to neuronal cells; Contradictory roles of heme as a toxic and a physiological molecule |
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Neurotoxic effects of hemeAcute damage; Chronic damage; Neuroglobin, hemoglobin and their neuroprotective roles; Heme oxygenases and neurodegenerative diseases: Where does heme come from?; Emerging regulatory roles for heme in neurons; Neurotrophic effects of heme; Heme can act as a gas-sensing regulator of brain functions; Heme and brain aging: Role of heme for protection from drug-induced neurotoxicity; May sufficient availability of heme delay aging?; Deficiency of heme and Alzheimer's disease; Heme in circadian pathways; References; Chapter 6 Heme and microRNA Biogenesis Feng Guo |
| Summary |
This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction to the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. Finally, an up-to-date review of human diseases associated with heme synthesis and application of heme synthesis in photodynamic therapy in cancer treatment is presented. Heme biology is unified and logical in presentation. It is well suited for students and professionals in life sciences who wish to comprehend the fascinating biology of heme and its usefulness in health and diseases. It may also be used as a reference book for advanced readers and researchers who are interested in heme biology. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary information for researchers to have an in-depth molecular understanding of heme biology and further their studies in this fascinating realm |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Heme.
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Heme -- biosynthesis
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Heme
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SCIENCE -- Life Sciences -- Molecular Biology.
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Heme
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Häm
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Biosynthese
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Häm.
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| Form |
Electronic book
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| Author |
Zhang, Li (Biological science professor)
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| ISBN |
9789814287937 |
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9814287938 |
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1283433311 |
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9781283433310 |
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