Cover -- Contents -- Acknowledgments -- Abbreviations -- Abstract -- 1 Introduction -- 1.1 Heart failure -- 1.1.1 Pathophysiology of HF -- 1.1.2 Integration of Cardiac and Vascular Changes -- 1.1.3 Compensatory mechanisms in HF -- 1.1.4 Clinical presentation -- 1.1.5 Therapy and prognosis -- 1.1.6 Acute management strategies -- 1.2 Heart failure models -- 1.3 ECLS -- 1.3.1 Definition of ECLS -- 1.3.2 History of ECLS -- 1.3.3 Indications and incidence of ECMO -- 1.3.4 Anatomy of ECMO -- 1.3.5 Pathophysiology of VA ECMO -- 1.3.6 Monitoring of ECMO circuit -- 1.3.7 Complications of ECMO
1.3.8 Hemodynamics of VA ECMO -- 2 Hypotheses -- 3 Aims -- 4 Methodology -- 4.1 Animal model of chronic heart failure -- 4.2 Animal model of acute HF induced by regionalcoronary hypoxemia -- 4.3 Animal model of acute HF induced by globalcoronary hypoxemia -- 4.4 Animal model of right-sided HF -- 4.5 Experimental preparation and hemodynamicmonitoring -- 4.6 Left ventricular parameters and stroke workanalysis -- 4.7 ECMO instrumentation -- 4.8 Experimental ECMO protocols and data acquisition -- 4.9 Statistical analysis -- 5 Results -- 5.1 Characteristics of developed chronic HF model
5.2 Characteristics of acute HF model induced byregional coronary hypoxemia -- 5.3 Characteristics of acute HF model induced byglobal coronary hypoxemia -- 5.4 Characteristics of right-sided HF model -- 5.5 Effects of EBF on chronic HF -- 5.6 Effects of EBF on acute HF -- 6 Discussion -- 6.1 Comments on HF animal models -- 6.2 EBF effects on chronic HF -- 6.3 EBF effects on acute HF -- 6.4 Correlation of tissue saturation and perfusion -- 6.5 Effects of flow pulsatility -- 6.6 Clinical considerations -- 6.7 Study limitations -- 7 Conclusions -- 8 List of linked documents -- 9 References
