Principles of protein structure -- A study in scarlet -- Allosteric theory -- Hemoglobin structure and allosteric mechanism -- Evolution of the vertebrate globin gene family -- Gene duplication and hemoglobin isoform differentiation -- The evolution of novel hemoglobin functions and physiological innovation -- Biochemical adaptation to environmental hypoxia -- Darwin's molecule
Summary
Provides a synthesis of our current understanding of hemoglobin (Hb) function and evolution, and illustrates how research on this protein has provided more general insights into mechanisms of protein evolution and biochemical adaptation
