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Author Rooke, Thom W.

Title The quest for cortisone / Thom Rooke
Published East Lansing [Mich.] : Michigan State University Press, [2012]
©2012
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Description 1 online resource (276 pages)
Contents Introduction -- Addison and his disease -- Introducing Dr. Kendall -- Life after the thyroid -- Introducing Dr. Hench -- Nice guys, saints, eccentrics, and geniuses -- 1929 and the decision to hunt for cortisone -- Another Kendall false start, another great announcement -- Kendall strikes out again -- Kendall presses on -- Score: Szent-Györgyi-1; Kendall-0 -- Transitions and travels -- War looms -- Hench meets Kendall -- World War II and military steroid research -- Plants, politicians, and more pessimism -- Good-bye Marker, hello Sarett -- Hench returns to Mayo -- Push on? Give up? -- The decision to test compound E on rheumatoid arthritis -- The amazing Mrs. G. -- A promising start -- The bad and the ugly -- Progress and setbacks -- Convincing the skeptics -- Announcement -- The prize -- Stockholm -- Aftermath -- Twilight -- The end of the show -- Notes
Summary "In 1948, when "Mrs. G.," hospitalized with debilitating rheumatoid arthritis, became the first person to receive a mysterious new compound -- cortisone -- her physicians were awestruck by her transformation from enervated to energized. After eighteen years of biochemical research, the most intensively hunted biological agent of all time had finally been isolated, identified, synthesized, and put to the test. And it worked. But the discovery of a long-sought "magic bullet" came at an unanticipated cost in the form of strange side effects. This fascinating history recounts the discovery of cortisone and pulls the curtain back on the peculiar cast of characters responsible for its advent, including two enigmatic scientists, Edward Kendall and Philip Hench, who went on to receive the Nobel Prize. The book also explores the key role the Mayo Clinic played in fostering cortisone's development, and looks at drugs that owe their heritage to the so-called "King of Steroids.""--Project Muse
Bibliography Includes bibliographical references
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
Print version record
Subject Hench, Philip S. (Philip Showalter), 1896-1965.
Kendall, Edward C. (Edward Calvin), 1886-1972.
Mayo Clinic.
Cortisone -- History.
Drug development.
Cortisone -- history.
Clinical Trials as Topic -- history.
Cortisone -- therapeutic use.
Drug Discovery -- history.
Drug Evaluation -- history.
History, 20th Century.
United States.
Genre/Form History.
Form Electronic book
LC no. 2011031277
ISBN 1609173260 (electronic bk.)
1628951257 (electronic bk.)
1628961252 (electronic bk.)
9781609173265 (electronic bk.)
9781628951257 (electronic bk.)
9781628961256 (electronic bk.)