| Description |
1 online resource |
| Contents |
Front Cover; Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March; Copyright; Contents; List of Contributors; Introduction; 1 -- The Maturation of Immune Function in Pregnancy and Early Childhood; Introduction; Immune development in health and disease; Early life immune regulation; Interplay of innate and adaptive immune regulation in organ-specific responses; Key influences and determinants of early immune function and regulation; Genetic factors; Direct effects of maternal allergy on immune maturation; Maternal environmental exposures and immune maturation |
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Early postnatal exposures and immune maturationModulating early immune development to promote immune regulation; Conclusion; References; 2 -- Immunological Aspects of the Atopic March; Introduction; Global inventory of the developmental pattern of allergen-specific antibody; Tentative interpretation of phases observed in the serological picture; The trends of IgE levels to allergenic sources; Immunoglobulin E trends examined at a molecular level; Discussion; References; 3 -- Atopic Dermatitis in Infancy and Childhood; Definition; Family history and genetics; Natural history of disease |
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Allergic sensitization and allergy as comorbidityRhinitis and asthma as comorbidity; Urticaria as comorbidity; Determinants of the disease; Socioeconomic status; Infant feeding; Domestic environment; Key elements of treatment; Prevention; Long-term outcome in adulthood; References; Further reading; 4 -- Adverse Reactions to Food; Clinical presentation of food allergy in infancy; Epidemiology and natural course; Pathogenesis; Diagnostic; Therapy; Immunotherapy for food allergy; References; Further reading; 5 -- Viral-Induced Wheeze and Asthma Development; Introduction |
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Longitudinal studies of childhood wheezingEtiology of wheezing illnesses in infancy; Risk factors for virus-induced wheezing; Progression from virus-induced wheezing to asthma; Do severe viral respiratory infections in infancy cause asthma?; Conclusions; References; 6 -- Infantile Lung Function and Airway Hyperresponsiveness; Introduction; Lung development; Lung function measurements; Lung function development; Postnatal impact on lung function development; Factors that may influence in utero lung function development; Infantile AHR; Summary and conclusion; References |
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7 -- The Development of Allergic Rhinitis in ChildhoodIncidence; Period prevalence; Sex differences; Comorbidity; The role of sensitization; Early predictors; Protective factors; Principles of therapy; Options for prevention; References; Further reading; 8 -- Genes and Atopic Phenotypes; Introduction; Tools for disentangling the genetics of atopy; Do genes co-associated with multiple childhood atopy phenotypes represent atopic march candidate genes?; Summary and conclusions; References; 9 -- Epigenetic Factors Before and After Birth; Introduction; Principles of epigenetic mechanisms |
| Summary |
Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world. As the natural history of these chronic diseases has been extensively studied, including their major genetic, environmental, and lifestyle determinants and potential protective factors, the book presents tactics on how pediatric allergists can provide early intervention. In addition, the book unites key, global experts in the field who summarize their collective, and current, knowledge of the early stage of the "Atopic March", along with novel ideas for potential options of prevention. Summarizes the current knowledge of the epidemiological, genetic, and cellular basis of allergic diseases Ideal reference for the study of allergies in young children, atopic dermatitis, allergic rhinitis, childhood asthma, and food allergies Provides landmark findings in the field of immunology and allergy development Fulfills the need for a book that focuses on primary and secondary allergy prevention, especially during the first years of life Unites key, global experts in the field who summarize their collective, and current, knowledge, along with novel ideas for potential options of prevention |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Online resource; title from PDF title page (EBSCO, viewed September 22, 2015) |
| Subject |
Allergy in children.
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Developmental immunology.
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Immunity.
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Children.
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Infants.
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Child
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Hypersensitivity -- immunology
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Infant
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Early Medical Intervention
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Hypersensitivity -- prevention & control
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Immune System Phenomena -- physiology
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Immunity
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children (people by age group)
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infants.
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MEDICAL -- Gynecology & Obstetrics.
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Infants
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Children
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Allergy in children
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Developmental immunology
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Immunity
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| Form |
Electronic book
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| Author |
Wahn, U. (Ulrich)
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Sampson, Hugh A.
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| ISBN |
9780127999302 |
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0127999302 |
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