| Description |
1 online resource (807 pages) |
| Contents |
Front Cover; Preface; Contents; Contributors; Chapter 1; A Global View of Immunological Development and Biology; I. KEY PLAYERS OF THE IMMUNE SYSTEM; A. Key Cell Types; 1. T Lymphocytes; 2. B Lymphocytes; 3. Polymorphonuclear Leukocytes; 4. Monocytes/Macrophages; 5. Dendritic Cells; 6. Natural Killer Cells; B. Soluble Factors; 1. Antibodies; 2. Cytokines; 3. Chemokines; 4. Complement Proteins; C. Cell-Associated Proteins; 1. Antigen-Presenting Proteins; 2. B-Cell and T-Cell Receptors; 3. Signaling Components; 4. Co-receptors; 5. Co-stimulatory Proteins; 6. Adhesion Proteins |
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II. LYMPHOID ORGANSA. Primary Lymphoid Organs; 1. Thymus; 2. Bone Marrow; B. Secondary Lymphoid Organs; 1. Lymph Nodes; 2. Spleen; III. LYMPHOCYTE DEVELOPMENT; A. B-Cell Development; B. T-Cell Development; IV. THE INNATE IMMUNE RESPONSE; A. Pattern Recognition Receptors; B. NK Cells and Receptors; C. Unusual Lymphocyte Subsets; V. THE ADAPTIVE IMMUNE RESPONSE; VI. CONCLUSION; REFERENCES; Chapter 2; Common Signaling in the Neuroendocrine and Immune Systems; I. INTRODUCTION; II. EFFECT OF IMMUNE SYSTEM COMMUNICATION TO NEUROENDOCRINE CELLS |
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III. NEUROENDOCRINE HORMONES AND THEIR RECEPTORS ON IMMUNE CELLSA. Pro-opiomelanocortin-Derived Peptides; B. TSH/TRH; C. Gonadotropins; D. VIP; E. PRL/GH; F. Opioid and Nonopioid Endorphins; IV. CLASS I CYTOKINE RECEPTOR SUPERFAMILY; V. IMMUNOREGULATORY EFFECTS OF PRL/GH; VI. SIGNALING PATHWAYS A. Jak Familyof Tyrosine Kinases; A. Jak Family of Tyrosine Kinases; B. Ras/Raf/MAPK Pathways; C. Phosphatidylinositol-3-Kinase; D. Other Signaling Mechanisms Activated byPRL; VII. MOLECULAR BASIS FOR THE NEUROENDOCRINE-IMMUNE INTERACTIONS; A. Jak/STAT Pathway; 1. Immune System |
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2. Neuroendocrine SystemVIII. CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3; Hypothalamic-Pituitary-Adrenal Axis Effects on Innate and Adaptive Immunity; I. INTRODUCTION; II. THE HPA AXIS; III. CYTOKINES AND THE HPA AXIS RESPONSE TO STRESS; IV. PROINFLAMMATORY EFFECTS OF PERIPHERAL, IMMUNE CRH; V. EFFECTS OF GLUCOCORTICOIDS ON THE IMMUNE RESPONSE; A. Antigen Presentation; B. Immune Cell Traffic, Proliferation, and Activity; C. Pro- and Anti-inflammatory CytokineProduction; REFERENCES; Chapter 4; Glucocorticoids and the Immune System; I. HISTORICAL OVERVIEW |
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II. SUPPRESSIVE EFFECTS OF GLUCOCORTICOIDS ON THE IMMUNE SYSTEMIII. STIMULATORY EFFECTS OF GLUCOCORTICOIDS ON THE IMMUNE SYSTEM; IV. GLUCOCORTICOIDS AND T-HELPER-CELL DIFFERENTIATION; V. GLUCOCORTICOIDS AND T-CELL DEVELOPMENT/SELECTION ; A. Glucorticoid Production by the Thymus; B. Interaction Between GR- and TCR-Mediated Signaling; CONCLUDING REMARKS; ACKNOWLEDGMENTS; REFERENCES; Chapter 5; Cytokines and Leptin as Mediators of the Hypothalamo-Pituitary-Adrenal Axis; I. INTRODUCTION; II. CYTOKINES AS MEDIATORS OF THE HPA AXIS; A. Hypothalamic Level; 1. Loss of BBB Integrity |
| Summary |
One of the first comprehensive references dealing specifically with this new field of interdisciplinary research in medicine, Immunoendocrinology in Health and Disease offers a full scientific picture of where the immune and neuroendocrine systems intersect-placing current understanding of system components, mechanisms, and functions side by side with clinical results illustrating the many ramifications of their interaction in human health and disease management |
| Notes |
2. Saturable Transport System |
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Print version record |
| Subject |
Endocrinology.
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Immunity -- Endocrine aspects.
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Neuroendocrinology.
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Endocrinology
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Neuroendocrinology
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Endocrinology
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Immunity -- Endocrine aspects
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Neuroendocrinology
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| Form |
Electronic book
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| ISBN |
9781135539306 |
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1135539308 |
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