Title Gene therapy for autoimmune and inflammatory diseases / edited by Yuti Chernajovsky and Paul D. Robbins

Published Basel : Birkhäuser, ©2010

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Description 1 online resource (xi, 239 pages) : illustrations Series Milestones in drug therapy Milestones in drug therapy. Contents Cover -- Table of Contents -- List of Contributors -- Preface -- Gene Therapy for Arthritis -- Why Gene Therapy in Arthritis? -- Ex Vivo Strategy -- In Vivo Strategy -- Vectors for Gene Transfer in Arthritis -- The Target Genes -- Different Promoter to Provide Safe and Targeted Gene Expression -- What Have We Learnt From Preclinical Studies? -- Clinical Experience of Gene Therapy in Ra -- Conclusion -- References -- Gene Therapy for the Treatment of Inflammatory Bowel Disease -- Inflammatory Bowel Disease -- Pathogenesis of Ibd -- Treatment of Ibd 8211; Current Clinical Standards -- Pharmacologic Therapy -- Surgical Therapy -- New Approaches to the Treatment of Ibd -- Blocking Pro-Inflammatory Cytokine Activity -- Anti-Inflammatory Cytokine Treatment -- T Cell Inhibition -- Promoting Intestinal Repair -- Modifying the Enteric Microbiota -- Applications of Nucleic Acid-Based Therapies in Ibd Treatment -- Concluding Remarks -- References -- Gene Therapy for Diabetes -- Introduction -- Approaches for Treating Type 1 Diabetes By Gene Transfer -- Prevention of Autoimmunity By Gene Therapy -- Islet Transplantation With Immunoregulatory Gene Transfection -- Induction of Insulin-Producing Cells From Stem/Progenitor Cells By Gene Transfection -- Reversible Immortalization of Pancreatic 946; Cells By Gene Transfer and Site Specific Recombination -- Conclusions -- References -- Gene Therapy for Cystic Fibrosis Lung Disease -- Introduction -- Cftr Mutations -- Pathophysiology of Cf Lung Disease -- The Low Volume Hypothesis to Explain Cf Lung Disease -- Pharmacological Approaches to Treat Cf Lung Disease -- Drugs That Increase Cftr Protein Levels -- Cftr Correctors, Drugs to Increase Trafficking of Cftr -- Cftr Potentiators, Drugs That Increase Conductance At the Apical Membrane -- Modulation of Other Ion Channels -- Gene Therapy Clinical Trials -- Adenovirus and Adeno-Associated Virus -- Negative Strand Rna Viruses -- Lentiviruses -- Non-Viral Vectors for Cf Gene Therapy -- Cationic Polymers As Mediators for Cf Plasmid Dna Gene Therapy -- Modifier Genes and Future Directions -- Conclusion -- References -- Gene Therapy of Multiple Sclerosis -- Introduction -- Modulation of T Cells By Cytokines -- Interferon-946; -- Interleukin-4 -- Interleukin-10 -- Th17-Treg Cytokines Family -- Decoy Receptors -- Immunotoxins -- Induction of Tolerance -- Innate Immune System -- Angiogenesis -- Antioxidative Therapy -- Stem Cell Mediated Gene Therapy -- Conclusions -- References -- Gene Therapy for Myositis -- Introduction -- Diagnosis -- Immunopathogenesis -- Conventional Therapies -- Gene Therapy -- Gene Therapy in Inflammatory Muscle Disorders -- Targets for Gene Therapy -- Conclusion and Outlook -- References -- Gene Therapy for Osteoarthritis -- Introduction: Osteoarthritis a Disease of Eroding Cartilage -- Current Approaches to Treatment -- Articular Cartilage Matrix Composition and Oa -- Mediator Summary This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy Bibliography Includes bibliographical references and index Notes Print version record In Springer eBooks Subject Autoimmune diseases -- Gene therapy Inflammation -- Gene therapy Toxicology. Autoimmune Diseases -- therapy Genetic Therapy -- methods Inflammation -- therapy Toxicology toxicology. medicines (material) MEDICAL -- Immunology. Biomédecine. Sciences de la vie. Gene therapy Immunology Medicine Rheumatology Toxicology Autoaggressionskrankheit Entzündung Gentherapie Entzèundung. Form Electronic book Author Chernajovsky, Yuti. Robbins, Paul D. LC no. 2010905304 ISBN 9783034601658 3034601654 9783034601641 3034601646

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