Description |
1 online resource (xv, 528 pages) : illustrations (some color) |
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illustration |
Series |
RSC drug discovery series, 2041-3203 ; 26 |
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RSC drug discovery series ; 26. 2041-3203
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Contents |
Section 1. Arachidonic acid cascade -- section 2. Kinases -- section 3. GPCRs -- section 4. Sphingolipids -- section 5. Steroid hormone receptors |
Summary |
Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medicinal chemistry literature for each target, ranging from components of the arachadonic acid cascade, to kinases, GPCRs, sphingolipids and others, to summarize its background biology and detail new insights, major advances and issues related to bringing new anti-inflammatory therapies to market. Consisting of five main sections key targets covered will include the AA Cascade: mPGES1, cPLA2, Leukotriene A4 Hydrolase, CRTH2; Kinases: P38/PDE4, MAPKAP Kinase 2 (MK2), Syk Kinase Inhibitors, Jak Kinases, IKK, Bruton's Tyrosine Kinase; GPCRs: CCR1, CCR2 Antagonists, CB2 Agonists; Sphingolipids: S1P1 Receptor Agonists, Sphingosine Lyase and Sphingosine Kinase 1 and a final miscellaneous section that looks at Non-Steroidal Dissociated Glucocorticoid Receptor Agonists. The book will be essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in industry and academia."-- Provided by publisher |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
Subject |
Anti-inflammatory agents -- Research
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Anti-inflammatory agents -- Therapeutic use -- Technological innovations
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Inflammation -- Treatment -- Research
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Pharmaceutical chemistry.
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Pharmacology.
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Chemistry.
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Life sciences.
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Physical sciences.
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Anti-inflammatory agents.
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Investigative Techniques
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Chemistry, Pharmaceutical
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Therapeutic Uses
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Analytical, Diagnostic and Therapeutic Techniques and Equipment
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Pharmacology
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Pharmacologic Actions
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Chemistry
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Biological Science Disciplines
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Chemical Actions and Uses
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Natural Science Disciplines
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Chemicals and Drugs
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Disciplines and Occupations
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Drug Discovery
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Anti-Inflammatory Agents
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pharmacology.
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chemistry.
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biological sciences.
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physical sciences.
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Chemistry.
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Biochemistry.
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MEDICAL -- Pharmacology.
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Anti-inflammatory agents
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Chemistry
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Life sciences
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Pharmaceutical chemistry
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Pharmacology
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Physical sciences
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Form |
Electronic book
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Author |
Levin, Jeremy Ian, 1956-
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Laufer, Stefan.
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ISBN |
9781849735346 |
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1849735344 |
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