| Description |
1 online resource (xiii, 343 pages) : color illustrations |
| Series |
2012-2013 Springer E-Books - Biomedical & Life Sciences
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| Contents |
Part I: The Foundation of IBD Genetics, Human and Animal Studies. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges / Xinjun Cindy Zhu and Richard P. MacDermott -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies / Jonas Halfvarson -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease / Emiko Mizoguchi, Atsushi Mizoguchi and Atul K. Bhan -- Part II: The Genetic and Molecular Makeup of Inflammatory Bowel Disease. Complex Disease Genes and Their Discovery / Jeffrey C. Barrett and Mark J. Daly -- The Genetics of Crohn's Disease / Andre Franke and Miles Parkes -- Genetics of Ulcerative Colitis / Mauro D'Amato, Catherine Labbé and John D. Rioux -- Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases / Charlie W. Lees and Alexandra Zhernakova -- Molecular Profiling of IBD Subtypes/Response to Therapy / Isabelle Cleynen and Séverine Vermeire -- Epigenetics of Inflammatory Bowel Disease / Robert Häsler, Stefan Schreiber and Stephan Beck -- Part III: Pathogenetic Pathways in Inflammatory Bowel Disease. Nod1 and Nod2 and the Immune Response to Bacteria / Maria Kaparakis-Liaskos, Dana J. Philpott -- The IL23-Th17 Axis in Intestinal Inflammation / Kevin J. Maloy -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics / Natalia B. Nedelsky, Petric Kuballa and Adam B. Castoreno -- The Epithelial Barrier / Stefan Koch, Asma Nusrat and Charles A. Parkos -- Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" / Nouara Lhocine and Philippe J. Sansonetti -- Cytokines in Inflammatory Bowel Disease / Matthias A. Engel and Markus F. Neurath -- Part IV: Concluding Remarks and Future Perspectives. Towards Personalized Therapy in Inflammatory Bowel Disease / Dermot P.B. McGovern |
| Summary |
Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn?s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed October 7, 2013) |
| Subject |
Inflammatory bowel diseases -- Genetic aspects
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Inflammatory bowel diseases -- Molecular aspects
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Inflammatory Bowel Diseases -- genetics
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Human genetics
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Medicine
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Molecular biology
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| Form |
Electronic book
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| Author |
D'Amato, Mauro, editor
|
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Rioux, John D., editor
|
| ISBN |
9781461482567 |
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1461482569 |
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