Dental fluorosis -- Fluoride content of teeth -- Fluoride's action in preventing dental caries -- Histopathology of dental fluorosis -- Diagnostic issues in dental fluorosis -- Indexes for dental fluorosis -- Dental fluorosis and fluoride intake -- Prevalence of dental fluorosis -- Risk factors in dental fluorosis -- Relation between dental fluorosis and caries -- Fluoride exposure and risk of bone fracture -- Bone fracture in humans -- Bone fracture in animals -- Reproductive effects of fluoride -- Reproductive effects in humans -- Reproductive effects in animals -- Effects of ingested fluoride on renal, gastrointestinal and immune systems -- Effects on the renal system -- Effects on the gastrointestinal system -- Hypersensitivity and immunological effects -- Genotoxicity of fluoride -- In vitro genotoxicity test systems -- In vivo genotoxicity test systems -- Proposed mechanisms of genotoxicity -- Carcinogenicity of fluoride -- Fluoride carcinogenicity in humans -- Fluoride carcinogenicity in animals
(Cont) Intake, metabolism and disposition of fluoride -- Fluoride intake -- Fluoride absorption -- Fluoride in plasma -- Tissue distribution -- Fluoride excretion
Summary
This book reviews the effects on health of fluoride ingested from various sources. Those health effects reviewed include dental fluorosis; bone fracture; effects on renal, reproductive, and gastrointestinal systems; and genotoxicity and carcinogenicity. The book also reviews the Environmental Protection Agency's current drinking-water standard for fluoride and considers future research needs
