The discovery of JNK and its biological functions / Ewen Gallagher and Michael Karin -- Regulation of JNK by small GTPases / Maria Julia Marinissen and J. Silvio Gutkind -- Physiological roles of the different JNKs: lessons from the JNK knockouts / Kanaga Sabapathy -- The biological function of JNKKs (mkk4/mkk7 knockout mice) / Hiroshi Nishina and Toshiaki Katada -- The JNK signal transduction pathway in drosophila / Changwan Lu and Steven X. Hou -- Regulation of apoptosis by the JNK signaling pathway / Anning Lin -- Oxidative stress, JNK activation and cell death / Han-Ming Shen and Zheng-gang Liu -- JNK as a therapeutic target / Brydon L. Bennett and Yoshitaka Satoh -- Therapeutic potential
Summary
Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecular mechanisms that govern cellular functions. The intracellular signaling network, which is composed of many signaling pathways, regulates most, if not all, fundamental cellular activities, from proliferation to programmed cell death (apoptosis). Ove
