| Description |
1 online resource |
| Contents |
Cover; Title Page; Copyright Page; Dedication; Contents; List of contributors; About the Author; Foreword; Preface; Chapter 1 -- Amphioxus as a Model for Understanding the Evolution of Vertebrates; 1.1 -- Brief introduction of amphioxus; 1.2 -- Biology of amphioxus; 1.2.1 -- Reproduction and embryogenesis of amphioxus; 1.2.2 -- Anatomy of amphioxus; 1.3 -- The story of amphioxus and early research studies in China; References; Chapter 2 -- Basic Knowledge of Immunology; 2.1 -- Immune organs; 2.1.1 -- Primary lymphoid organs; 2.1.1.1 -- Bone marrow; 2.1.1.2 -- Thymus; 2.1.2 -- Secondary lymphoid organs |
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2.1.2.1 -- Lymph nodes2.1.2.2 -- Spleen; 2.1.2.3 -- Mucosa-associated lymphoid tissue; 2.2 -- Immune cells; 2.2.1 -- Lymphoid cells; 2.2.1.1 -- B cells; 2.2.1.2 -- T cells; 2.2.1.3 -- NK cells; 2.2.2 -- Innate immunity-associated cells; 2.2.2.1 -- Neutrophils; 2.2.2.2 -- Macrophages; 2.2.2.3 -- Dendritic cells; 2.3 -- Innate immunity; 2.3.1 -- Toll-like receptors involved in the signaling pathway; 2.3.2 -- NOD-like receptors and their functions; 2.3.3 -- RIG-like receptors; 2.3.4 -- C-type lectins; 2.3.5 -- The scavenger receptors; 2.3.6 -- Inflammation; 2.4 -- Adaptive immunity; 2.4.1 -- Specificity |
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2.4.2 -- Diversity2.4.3 -- Immunological memory; 2.4.4 -- Self-nonself recognition; 2.5 -- Complement system; 2.5.1 -- Complement pathways; 2.5.1.1 -- Classical pathway; 2.5.1.2 -- Lectin pathway; 2.5.1.3 -- Alternative pathway; 2.5.2 -- Complement in host defense; References; Chapter 3 -- Immune Organs and Cells of Amphioxus; 3.1 -- Introduction; 3.2 -- Organs of the amphioxus immune system; 3.2.1 -- Amphioxus gill slits: the first immune defense line; 3.2.2 -- Amphioxus intestine: not just a digestive organ but also an immune organ; 3.3 -- Cells of the amphioxus immune system; 3.3.1 -- Phagocytes |
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3.3.2 -- Lymphocyte-like cellsReferences; Chapter 4 -- Genomic and Transcriptomic View of Amphioxus Immunity; 4.1 -- Introduction; 4.2 -- Trace evidence of adaptive immunity; 4.2.1 -- TCRs, Igs, VLRs, and the origins of RAG; 4.2.2 -- MHC and genes involved in antigen presentation; 4.3 -- Extraordinary gene expansion in amphioxus innate immunity; 4.3.1 -- The TLR system; 4.3.2 -- The NLR system; 4.3.3 -- LRRIG proteins; 4.3.4 -- Other LRR-containing genes; 4.3.5 -- C-type lectins; 4.3.6 -- Scavenger receptors; 4.3.7 -- RIG-I-like helicases; 4.3.8 -- Complement-related receptors; 4.3.9 -- The TNF system |
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4.3.10 -- Expansion and reshuffling of the death-fold domains4.3.11 -- Expansion of TIR adaptors, TRAFs, and initiator caspases; 4.3.12 -- Cytokines, kinases, and transcription factors; 4.4 -- Regulation of the amphioxus immune system; 4.4.1 -- Differential regulatory patterns between expanded gene families; 4.4.2 -- The regulation during bacterial infection; 4.4.3 -- The regulation of the terminal signaling network; 4.4.4 -- Differential expression patterns observed within TNF and IL-1R systems; 4.4.5 -- Major pathways in a complex signaling network; 4.4.6 -- A functional prototypic complement system |
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4.4.7 -- The prototype of the oxidative burst-like system |
| Summary |
Annotation 'Amphioxus Immunity' covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed January 13, 2016) |
| Subject |
Amphioxus -- Physiology
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Immune system.
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Marine invertebrates -- Physiology.
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Immunity.
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Lancelets
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Lancelets -- immunology
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Immunity
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Immunity
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Immune system
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Marine invertebrates -- Physiology
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| Form |
Electronic book
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| Author |
Xu, Anlong, editor.
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| ISBN |
9780128096475 |
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0128096470 |
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0128499036 |
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9780128499030 |
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