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Title Twenty years of G-CSF : clinical and nonclinical discoveries / Graham Molineux, MaryAnn Foote, Tara Arvedson, editors
Published Basel : Springer, [2012]
Online access available from:
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Description 1 online resource (xxii, 471 pages) : illustrations
Series Milestones in drug therapy
Milestones in drug therapy.
Contents pt. 1. Basic science -- pt. 2. Use of rHuG-CSF in the oncology setting -- pt. 3. Use of rHuG-CSF in non-oncology setting -- pt. 4. Safety and economics -- pt. 5. The next 20 years
Summary Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF
Analysis Medicine
Cancer Research
Cytokines and Growth Factors
Bibliography Includes bibliographical references and index
Subject Filgrastim.
Granulocyte Colony-Stimulating Factor -- therapeutic use.
Leukemia, Myeloid -- drug therapy.
Leukocyte Disorders -- chemically induced.
Multiple Myeloma -- drug therapy.
Receptors, Granulocyte Colony-Stimulating Factor.
Form Electronic book
Author Molineux, G. (Graham)
Foote, MaryAnn.
Arvedson, Tara.
LC no. 2011944333
ISBN 9783034802185 (electronic bk.)
3034802188 (electronic bk.)