Title Gene function analysis / edited by Michael F. Ochs

Published Totowa, N.J. : Humana Press, ©2007

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Description 1 online resource (xiv, 337 pages) : illustrations Series Methods in molecular biology, 1064-3745 ; 408 Methods in molecular biology (Clifton, N.J.) ; v. 408 Contents Gene function inference from gene expression of deletion mutants / Ghislain Bidaut -- Association analysis for large-scale gene set data / Stefan A. Kirov, Bing Zhang, and Jay R. Snoddy -- Estimating gene function with least squares nonnegative matrix factorization / Guoli Wang and Michael F. Ochs -- From promoter analysis to transcriptional regulatory network prediction using PAINT / Gregory E. Gonye [and others] -- Prediction of intrinsic disorder and its use in functional proteomics / Vladimir N. Uversky [and others] -- Sybil : methods and software for multiple genome comparison and visualization / Jonathan Crabtree [and others] -- Estimating protein function using protein-protein relationships / Shailesh V. Date -- Bioinformatics tools for modeling transcription factor target genes and epigenetic changes / Ramana V. Dvuluri -- Mining biomedical data using MetaMap Transfer (MMTx) and the Unified Medical Language System (UMLS) / John D. Osborne [and others] -- Statistical methods for identifying differentially expressed gene combinations / Yen-Yi Ho [and others] -- Gene function analysis using the chicken B-cell line DT40 / Randolph B. Caldwell [and others] -- Design and application of a shRNA-based gene replacement retrovirus / Rugang Zhang, Peter D. Adams, and Xiaofen Ye -- Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells / Tsung-Lin Cheng and Wen-Tsan Chang -- Selection of recombinant antibodies from antibody gene libraries / Michael Hust, Stefan Dübel, and Thomas Schirrmann -- A bacterial/yeast merged two-hybrid system : protocol for yeast screening with single of parallel baits / Nadezhda Y. Tikhmyanova [and others] -- A bacterial/yeast merged two-hybrid system : protocol for bacterial screening / Ilya G. Serebriiskii, Nadia Milech, and Erica A. Golemis -- Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system / Stacey Thibodeau-Beganny and J. Keith Joung Summary With the advent of high-throughput technologies, the number of genes of interest has expanded and the traditional methods for gene function analysis cannot achieve the throughput necessary for large-scale exploration. In Gene Function Analysis, a select team of experts bring together a number of recently developed techniques for studying gene function. The volume begins with a variety of computational techniques, which provide an excellent point of departure for the cutting-edge experimental methods that follow. Written in the highly successful Methods in Molecular Biology series format, each chapter surveys its subject with readily reproducible laboratory protocols, a list of the necessary materials, and the popular Notes section, which contains tips for troubleshooting and avoiding known pitfalls. Comprehensive and timely, Gene Function Analysis offers researchers a clear guide and the important tools they need to further study the intricate human genome Analysis genen genes genexpressie gene expression moleculaire genetica molecular genetics bioinformatics biologische technieken biological techniques genexpressieanalyse genomics computational science genregulatie gene regulation protocollen protocols Molecular Genetics Bioinformatics (General) Moleculaire genetica Bioinformatica (algemeen) Bibliography Includes bibliographical references and index Notes English Print version record Subject Genetics -- Technique. Genetics -- Technique -- Laboratory manuals Genomics -- Methodology -- Laboratory manuals Genetic Techniques Computational Biology -- methods Databases, Genetic Genomics -- methods SCIENCE -- Life Sciences -- Genetics & Genomics. Génomique -- Méthodologie. Genetics -- Technique. Génétique -- Technique. Bio-informatique -- Méthodologie. Genetics -- Technique Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Ochs, Michael F. ISBN 9781597455473 1597455474 1588297349 9781588297341 1280971797 9781280971792 9786610971794 661097179X

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