| Description |
1 online resource (xii, 754 pages, 48 unnumbered pages of plates) : illustrations (some color) |
| Contents |
Evolutionary history of the genus Mus / Priscilla K. Tucker -- Visual and other sensory abilities of mice and their influence on behavioral measures of cognitive function / Aimée A. Wong and Richard E. Brown -- Comparative survey of the mammalian visual system with reference to the mouse / Catherine A. Leamey, Dario A. Protti and Bogdan Dreher -- Survey of the research opportunities afforded by genetic variation in the mouse visual system / Lawrence H. Pinto and John B. Troy -- The mouse as a model for myopia, and optics of its eye / Frank Schaeffel -- Characteristics and applications of mouse eye movements / John S. Stahl -- Measuring vision in the awake behaving mouse / Glen T. Prusky and Robert M. Douglas -- Electroretinographic correlates of normal and abnormal retinal ganglion cell activity / Vittorio Porciatti -- Aqueous humor dynamics and trabecular meshwork / Ernst R. Tamm and Antonia Kellenberger -- Recent advances in the investigation of mouse cone photoreceptors / Arkady Lyubarsky [and others] -- Mosaic architecture of the mouse retina / Benjamin E. Reese -- Synaptic organization of the mouse retina / Enrica Strettoi -- Distribution and functional roles of neuronal gap junctions in the mouse retina / Stewart A. Bloomfield and Béla Völgyi -- Neurotransmission in the mouse retina / Maureen A. McCall, Neal S. Peachey and Ronald G. Gregg -- Morphological, functional, and developmental properties of mouse retinal ganglion cells / Julie L. Coombs and Leo M. Chalupa -- The lamina cribrosa region and optic nerve of the mouse / Christian-Albrecht May -- Photoentrainment of the circadian oscillator / Satchidananda Panda -- Physiology of the mouse dorsal lateral geniculate nucleus / Matthew S. Grubb -- Superior colliculus and saccade generation in mice / Tomoya Sakatani and Tadashi Isa -- Interconnections of visual cortical areas in the mouse / Andreas Burkhalter and Quanxin Wang -- Chronology of development of the mouse visual system : comparisons with human development / Barbara L. Finlay and Barbara Clancy -- Developmental studies of the mouse lens : past, present, and future / Michael L. Robinson -- Development of the retinal vasculature and the effects of high oxygen (retinopathy of prematurity) / Michael R. Powers -- Specification, histogenesis, and photoreceptor development in the mouse retina / Deepak Lamba [and others] -- Rb and the control of retinal development / Michael A. Dyer -- Gene regulatory networks and retinal ganglion cell development / Xiuqian Mu and William H. Klein -- Cell death in the mouse retina / Lucia Galli-Resta and Maria Cristina Cenni -- The function of the retina prior to vision : the phenomenon of retinal waves and retinotopic refinement / Marla B. Feller and Aaron G. Blankenship -- On and Off pathways in the mouse retina and the role of stimulation / Ning Tian -- Retinoic acid function in central visual pathways / Ursula C. Drager, Tuanlian Luo and Elisabeth Wagner -- Intraretinal axon guidance / Lynda Erskine and Hannah Thompson -- Early development of the optic stalk, chiasm, and astrocytes / Timothy J. Petros and Carol A. Mason -- Axon growth and regeneration of retinal ganglion cells / Jeffrey L. Goldberg -- Development of the retinogeniculate pathway / William Guido -- Developmental synaptic remodeling : insights from the mouse retinogeniculate synapse / Chinfei Chen -- Ocular dominance plasticity / Mark Hübener, Sonja B. Hofer and Thomas D. Mrsic-Flogel -- Environmental enrichment and visual system plasticity / Alessandro Sale, Nicoletta Berardi and Lamberto Maffei -- Bidirectional experience-dependent plasticity in primary visual cortex / Mikhail Y. Frenkel and Mark F. Bear -- Mouse models : a key system in revolutionizing the understanding of glaucoma / Gareth R. Howell, Jeffrey K. Marchant and Simon W.M. John -- Cataract genetics / Jochen Graw -- Mouse models of infectious eye diseases / Linda D. Hazlett -- Mouse models of autoimmune and immune-mediated uveitis / Rachel R. Caspi -- Mouse models of Norrie disease / Wolfgang Berger -- The lipofuscin of retinal pigment epithelial cells : learning from mouse models of retinal disease / Janet R. Sparrow [and others] -- Studies of diabetic retinopathy using mice / Rose A. Gubitosi-Klug and Timothy S. Kern -- Roles of oxygen in the stability of photoreceptors : evidence from mouse and other models of human disease / Jonathan Stone and Krisztina Valter -- Complex genetics of photoreceptor light damage / Michael Danciger -- Age-related eye diseases / Bo Chang -- New genetic technologies for studying the morphology, physiology, and development of mouse retinal neurons / Tudor C. Badea and Jeremy Nathans -- Adenoassociated virus gene therapy in mouse models of retinal degeneration / Shannon E. Boye, Sanford L. Boye and William W. Hauswirth -- Delivery of plasmids into the visual system using electroporation / Takahiko Matsuda and Constance L. Cepko -- Genetic knockouts in ophthalmic research and drug discovery / Dennis S. Rice -- Beyond positional cloning of single gene mutations : use of mouse models to examine allelic variance and to identify genetic modifiers / Patsy M. Nishina and Juergen K. Naggert -- The mouse eye transcriptome : cellular signatures, molecular networks, and candidate genes for human disease / Eldon E. Geisert and Robert W. Williams -- Mouse models, microarrays, and genetic networks in retinal development and degenerative disease / Sunil K. Parapuram and Anand Swaroop -- Retinal vascular and retinal pigment epithelium gene expression / Michael I. Dorrell and Martin Friedlander -- Gene expression in cornea and lens / Shivalingappa K. Swamynathan and Joram Piatigorsky -- Proteomics of the mouse lens / Wolfgang Hoehenwarter and Peter R. Jungblut -- Genetic and proteomic analyses of the mouse visual cycle / John C. Saari and John W. Crabb |
| Summary |
A comprehensive guide to current research, reflecting recent technical breakthroughs that have established the usefulness of the mouse model as part of a bilateral exchange between experimental and clinical research. Recent years have seen a burst of studies on the mouse eye and visual system, fueled in large part by the relatively recent ability to produce mice with precisely defined changes in gene sequence. Mouse models have contributed to a wide range of scientific breakthroughs for a number of ocular and neurological diseases and have allowed researchers to address fundamental issues that were difficult to approach with other experimental models. This comprehensive guide to current research captures the first wave of studies in the field, with fifty-nine chapters by leading scholars that demonstrate the usefulness of mouse models as a bridge between experimental and clinical research. The opening chapters introduce the mouse as a species and research model, discussing such topics as the mouse's evolutionary history and the mammalian visual system. Subsequent sections explore more specialized subjects, considering optics, psychophysics, and the visual behaviors of mice; the organization of the adult mouse eye and central visual system; the development of the mouse eye (including comparisons to human development); the development and plasticity of retinal projections and visuotopic maps; mouse models for human eye disease (including glaucoma and cataracts); and the application of advanced genomic technologies (including gene therapy and genetic knockouts) to the mouse visual system. Readers of this unique reference will see that the study of mouse models has already demonstrated real translational prowess in vision research |
| Analysis |
NEUROSCIENCE/General |
|
NEUROSCIENCE/Visual Neuroscience |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Mice -- Sense organs
|
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Eye.
|
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Visual pathways.
|
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SOCIAL SCIENCE -- Anthropology -- Physical.
|
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Eye
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Mice -- Sense organs
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Visual pathways
|
| Form |
Electronic book
|
| Author |
Chalupa, Leo M.
|
|
Williams, Robert W., 1952-
|
| ISBN |
9780262270137 |
|
0262270137 |
|
