| Description |
1 online resource (xxiii, 1042 pages) : illustrations |
| Series |
Cell biology research progress |
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Cell biology research progress.
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| Contents |
MITOCHONDRIA: STRUCTURE, FUNCTIONS AND DYSFUNCTIONS -- MITOCHONDRIA: STRUCTURE, FUNCTIONS AND DYSFUNCTIONS -- Contents -- Preface -- Mitochondria: The Portrayal of an Executioner -- Abstract -- Introduction -- II. Apoptotic Pathways -- II. A. Extrinsic Pathways -- II. B. Perforin-Granzyme B Pathways -- II. C. Intrinsic Pathways -- II. D. Execution Pathway -- III. Mitochondria and Gateways to Mitochondrial Death -- III. A. Mitochondria and Cell -- III. B. Regulation of Mitochondrial Membrane Permeabilization -- III. B.1. Non-protein mediators -- Calcium |
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Lipid and lipid metabolitesSmall molecules -- III. B.2. Protein mediators: Bcl-2 family-intrinsic regulators of cellular life and death -- III. B.2.1. Properties of Bcl-2 family members -- III. B.2.2. Upstream of mitochondria: Activation of BCL-2 family members -- III. B.2.3. Post-translational modifications determine active/inactive conformations -- III. B.2.3.a. Dimerization -- III. B.2.3.b. Translocation -- III. B.2.3.c. Phosphorylation -- III. B.2.3.d. Cleavage -- III. B.2.3.e. Transcription -- III. B.2.4. Pro-apoptotic BCL-2 members as sentinels for cellular damage |
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III. C. Characteristics of Apoptotic Membrane PermeabilizationIII. D. Models of Mitochondrial Membrane Permeabilization -- III. D.1. Permeabilization of the inner membrane along with the rupture of the Outer Membrane -- III. D.2. The adenine nucleotide transporter -- III. D.3. BCL-XL and ADP/ATP Exchange -- III. D.4. Selective permeabilization of the Outer Mitochondrial Membrane -- III. D.5. Outer Membrane permeabilization by VDAC -- III. E. Mitochondrial Membrane Permeabilization and Released Factors -- III. E.1. Cytochrome c -- III. E.2. Daiblo/Smac -- III. E.3. HtrA2/Omi |
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III. E.4. Procaspase-2 and 9III. E.5. Hsp 10, Hsp60 -- III. E.6. AIF -- III. E.7. Release of Endonuclease G -- III. E.8. Adenylate Kinase 2 -- III. F. Outcome of Mitochondrial Membrane Permeabilization -- III. F.1. Apoptosome -- Active versus inactive apoptosomes -- The role of cytochrome c and dATP in apoptosome assembly and caspase-9 processing -- III. F.2. Breakdown of oxidative phosphorylation -- IV. PTPC Structure and Mitochondrial Permeability Transition- A Final Word -- V. Effects of Mitochondria Membrane Permeabilization |
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VI. Afferent Signals Form Other Organelles Inducing MMPVI. A. Nuclear DNA Damage -- VI. A.1. Signals from the “guardian of genome� to mitochondria -- VI. B. Endoplasmic Reticulum -- VI. C. Lysosomes -- VI. D. Cytosol -- VI. D.1. The ubiquitin/proteasome complex -- VI. D.2. The phosphatidylinositol-3-kinase pathway -- VI. D.3. Apoptosis signal-regulating kinase/mitogen-activated protein kinase -- VI. E. Cytoskeleton -- VII. Apoptosis, Mitochondria and Human Disease -- VII. A. Ischemia/Reperfusion -- VII. B. Aging and Mitochondrial Damage |
| Bibliography |
Includes bibliographicale references and index |
| Notes |
Print version record |
| Subject |
Mitochondria.
|
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Mitochondria -- physiology
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Mitochondria -- metabolism
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Mitochondria -- pathology
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Mitochondria
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SCIENCE -- Life Sciences -- Cell Biology.
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Mitochondria
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Mitochondriën.
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Pathologische fysiologie.
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| Form |
Electronic book
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| Author |
Svensson, Oliver L
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| ISBN |
9781613244814 |
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1613244819 |
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