Title Handbook of mitochondrial dysfunction / edited by Shamim I. Ahmad

Published Boca Raton, FL : CRC Press, [2019]

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Description 1 online resource Contents SECTION I: Introduction: structure and function of mitochondria -- Mitochondrial structure and function -- Structure, function and evolutionary aspects of mitochondria -- Mitochondrial genome damage, dysfunction and repair -- SECTION II: Mitochondrial dysfunction and diseases -- Instability of human mitochondrial DNA, nuclear genes and diseases -- Kearns-Sayre syndrome -- Mitochondrial dysfunction and Barth Syndrome -- Mitochondrial dysfunction in the pathophysiology of Alzheimer's disease -- Mitochondrial dysfunction in multiple sclerosis -- Mitochondrial dysfunction in chronic kidney disease -- Mitochondrial dysfunction in breast cancer: a potential target from the bench to clinical therapeutics -- Mitochondrial dysfunction and DNA methylation in atherosclerosis -- Mitochondrial dysfunction and heart diseases -- The roles of mitochondrial dysfunction in mitophagy and apoptosis and its relevance to cancer -- Mitochondrial dysfunction linking obesity and asthma -- Mitochondrial dysfunction and hearing loss -- Superoxide dismutase, mitochondrial dysfunction, and neurodegenerative diseases -- Role of post-translational modifications of mitochondrial complex I in mitochondrial dysfunction and human brain pathologies -- Heme oxygenase-1 in kidney health and disease: perspective of mitochondrial homeostasis -- Mitochondrial transplantation in myocardial ischemia and reperfusion injury -- Mitochondrial dysfunction in diabetes -- Clinical manifestation of mitochondrial disorders in childhood -- Mitochondrial dysfunction and epilepsies -- Mitochondrial dysfunction and allergic disease SECTION III: Factors affecting mitochondrial function -- Role of carnosic acid in protection of brain mitochondria -- Mitochondrial dysfunction and its impact on oxidative capacity of muscle -- The effects of resveratrol on the brain mitochondria -- Pathophysiology and biomarkers of mitochondrial dysfunction induced by heavy exercise -- Mitochondrial pathologies and their neuro muscular manifestations -- Mitochondrial stress and cellular senescence -- Role of mitochondrial dysfunction in human obesity -- Roles of melatonin in maintaining mitochondrial welfare: focus on renal cells -- Mitochondrial dysfunction affecting the peripheral nervous system in diabetic neuropathy and avenues for therapy -- Mitochondrial dysfunction and oxidative stress in the pathogenesis of metabolic syndrome -- SECTION IV: Immunity and toxicity -- Regulation of antiviral immunity by mitochondrial dynamics -- Mitochondrial dysfunction, immune systems, their diseases, and possible treatments -- Organophosphorus compound-induced mitochondrial disruption -- Itochondrial dysfunction in Friedreich Ataxia -- Index Summary Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria Bibliography Includes bibliographical references and index Notes Shamim I. Ahmadearned his Master's degree in Botany from Patna University, Bihar, India, and his PhD in Molecular Genetics from Leicester University, England. He then joined Nottingham Polytechnic as a grade 1 lecturer and subsequently was promoted to the post of Senior Lecturer. Ahmad now spends much of his time producing/writing medical books. For more than three decades he researched different areas of molecular biology/genetics including thymineless death in bacteria, genetic control of nucleotide catabolism, development of anti-AIDs drug, control of microbial infection of burns, phages of thermophilic bacteria, and microbial flora of Chernobyl after the nuclear power station accident. But his main interest is DNA damage and repair specifically by near-ultraviolet light mostly through the photolysis of biological compounds, production of reactive oxygen species, and their implications on human health including skin cancer. He also investigates near-ultraviolet photolysis of non-biological compounds such as 8-metoxypsoralen, mitomycin C, and their importance in psoriasis treatment and in Fanconi anemia. He has collaborated with the University of Osaka, Japan, and he and his colleagues were able to show that a number of naturally occurring enzymes were able to scavenge the reactive oxygen species. In 2003 he received a prestigious Asian Jewel Award in Britain for Excellence in Education. His long time ambition to produce medical books started in 2007 and since then he has published Molecular mechanisms of Fanconi Anemia, Molecular Mechanisms of Xeroderma Pigmentosum; Molecular Mechanisms of Cockayne Syndrome; Molecular Mechanisms of Ataxia Telangiectasia; Diseases of DNA repair; Neurodegenerative diseases; Diabetes: an Old Disease a New Insight, Obesity: a Practical Guide, Thyroid: Basic Science and Clinical Practice, and Ultraviolet light in Human Health, diseases and environment; also as a co-author the book on Diabetes: A comprehensive Treatise for patients and Caregivers. His most recent books are Reactive Oxygen Species in Biology and Human Health and Aging: Exploring a Complex Phenomenon Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL Online resource; title from digital title page (viewed on July 12, 2019) Subject Mitochondrial pathology -- Handbooks, manuals, etc Mitochondrial pathology. Mitochondria -- pathology HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. MEDICAL -- Pharmacology. SCIENCE -- Life Sciences -- Cytology. SCIENCE -- Life Sciences -- Biology -- Molecular Biology. Mitochondrial pathology Genre/Form handbooks. Handbooks and manuals Handbooks and manuals. Guides et manuels. Form Electronic book Author Ahmad, Shamim I. ISBN 9780429443336 0429443331 9780429811753 0429811756 9780429811777 0429811772 9780429811760 0429811764

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