| Description |
1 online resource (xv, 463 pages) : illustrations (some color) |
| Series |
Methods in molecular biology ; 1044 |
|
Methods in molecular biology (Clifton, N.J.) ; v. 1044. 1064-3745
|
| Contents |
Bacterial mutation assays / Errol Zeiger -- In vitro mouse lymphoma (L5178Y Tk+/- -3.7.2C) forward mutation assay / Melissa R. Schisler, Martha M. Moore, and B. Bhaskar Gollapudi -- Erythrocyte-based pig-a gene mutation assay / Jeffrey C. Bemis, Nikki E. Hall, and Stephen D. Dertinger -- Detection of in vivo mutation in the Hprt and pig-a genes of rat lymphocytes / Vasily N. Dobrovolsky [and others] -- In vivo cII, gpt, and spi- gene mutation assays in transgenic mice and rats / Mugimane G. Manjanatha [and others] -- In vitro cytogenetic assays : chromosomal aberrations and micronucleus tests / Julian Laubenthal [and others] -- Comet assay : assessment of in vitro and in vivo DNA damage / Mahima Bajpayee, Ashutosh Kumar, and Alok Dhawan -- Comet assay in human biomonitoring / Diana Anderson, Alok Dhawan, and Julian Laubenthal -- Comet assay in marine animals / Giada Frenzilli and Brett P. Lyons -- Unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo / Fabrice Nesslany -- 32P-postlabeling analysis of DNA adducts / Heinz H. Schmeiser, Marie Stiborova, and Volker M. Arlt -- Micronucleus assay with tetrad cells of tradescantia / Miroslav Mišík [and others] -- Wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila / Ricard Marcos and Erico R. Carmona -- Genotoxicity guidelines recommended by International Conference of Harmonization (ICH) / Gireesh H. Kamath and K.S. Rao |
| Summary |
Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences |
| Analysis |
farmacologie |
|
pharmacology |
|
toxicologie |
|
toxicology |
|
biomedische wetenschappen |
|
biomedicine |
|
humane genetica |
|
human genetics |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Genetic toxicology -- Laboratory manuals
|
|
Genetic screening.
|
|
Genetic Testing
|
|
Molecular Diagnostic Techniques
|
|
Mutation -- genetics
|
|
Genetic screening
|
|
Genetic toxicology
|
| Genre/Form |
Laboratory manuals
|
|
Laboratory manuals.
|
|
Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
Dhawan, Alok, editor
|
|
Bajpayee, Mahima, editor
|
| ISBN |
9781627035293 |
|
162703529X |
|
