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Title The plasticity of skeletal muscle : from molecular mechanism to clinical applications / Kunihiro Sakuma, editor
Published Singapore : Springer, [2017]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (ix, 292 pages) : illustrations (chiefly color)
Contents Pluripotent stem cells and skeletal muscle differentiation: challenges and immediate applications -- Role of the ubiquitin-proteasome pathway in skeletal muscle -- Stem cell therapy in muscle degeneration -- The autophagy-dependent signaling in skeletal muscle -- Cytokines in skeletal muscle growth and decay -- The role of ribosome biogenesis in skeletal muscle hypertrophy -- Comprehensive approach to sarcopenia and cachexia treatment -- The role and regulation of PGC-1[alpha] and PGC-1[beta] in skeletal muscle adaptation -- Characteristics of skeletal muscle as a secretory organ -- Biological role of TRPC1 in myogenesis, regeneration, and disease -- ROS and nNOS in the regulation of disuse-induced skeletal muscle atrophy -- Participation of AMPK in the control of skeletal muscle mass -- Therapeutic potential of skeletal muscle plasticity and slow muscle programming for muscular dystrophy and related muscle conditions
Summary This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demands, appears to endocrine various myokines, which flow into blood to protect the recognizing function of brain and inhibit the appearance of several cancer tumorigenesis. The book deals with current stem-cell based, pharmacological, and nutritional therapies for muscle wasting (sarcopenia, cachexia, and muscular dystrophy). It also explains the roles of biological mediators such as PGC-1, transient receptor potential cation channels (TRPC), and AMPK in modulating muscle function. The functional roles of ubiquitin-proteasome system, autophagy-dependent signaling in muscle homeostasis, ribosome biogenesis, and redox regulation of mechanotransduction to modulate skeletal muscle mass are also covered. It is an essential resource for physicians, researchers, post-docs as well as graduate students in the field of sports science including rehabilitation therapy, exercise physiology, exercise biochemistry, and molecular biology dealing with skeletal muscle
Bibliography Includes bibliographical references
Notes Online resource; title from electronic title page (ProQuest Ebook Central, viewed April 6, 2017)
Subject Skeleton -- Muscles.
Muscle, Skeletal -- metabolism.
Muscle, Skeletal -- physiology.
Muscular Atrophy -- metabolism.
Signal Transduction.
Stem Cells.
Form Electronic book
Author Sakuma, Kunihiro, editor
ISBN 9789811032929 (electronic bk.)
9811032920 (electronic bk.)
(hardcover ;) (alk. paper)
(hardcover ;) (alk. paper)