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Title Iron acquisition by the Genus Mycobacterium : history, mechanisms, role of Siderocalin, anti-tuberculosis drug development / B. Rowe Byers, editor
Published Cham ; New York : Springer, [2013]
©2013
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Description 1 online resource
Series SpringerBriefs in molecular science, Biometals, 2191-5407
SpringerBriefs in molecular science. Biometals.
Contents Introduction to the Book / B. Rowe Byers -- A History of Iron Metabolism in the Mycobacteria / Colin Ratledge -- Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers -- Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia -- Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu
Summary Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates
Analysis Life sciences
Emerging infectious diseases
RNA-ligand interactions
Microbiology
Inorganic Chemistry
Infectious Diseases
Notes Includes index
Bibliography cludes bibliographical references
Notes Print version record
Subject Mycobacteria -- Metabolism.
Iron -- Metabolism.
Iron -- metabolism.
Mycobacterium -- metabolism.
Form Electronic book
Author Byers, B. Rowe.
ISBN 9783319003030 (electronic bk.)
3319003038 (electronic bk.)
331900302X (print)
9783319003023 (print)