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Title Pathogenesis of mycobacterium tuberculosis and Its interaction with the host organism / Jean Pieters, John D. McKinney, editors
Published Heidelberg : Springer Berlin Heidelberg, [2013]
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Description 1 online resource (248 pages)
Series Current topics in microbiology and immunology ; v. 374
Current topics in microbiology and immunology ; 374
Contents Genetic Diversity in Mycobacterium tuberculosis / Sebastien Gagneux -- DNA Metabolism in Mycobacterial Pathogenesis / Digby F. Warner, Tone Tønjum and Valerie Mizrahi -- Molecular Biology of Drug Resistance in Mycobacterium tuberculosis / Tasha Smith, Kerstin A. Wolff and Liem Nguyen -- Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations / John D. Szumowski, Kristin N. Adams, Paul H. Edelstein and Lalita Ramakrishnan -- Getting Across the Cell Envelope: Mycobacterial Protein Secretion / Aniek D. van der Woude, Joen Luirink and Wilbert Bitter -- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria / Giulia Manina and John D. McKinney -- Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes / Sabine Ehrt and Kyu Rhee -- Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis / Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters -- Host-Pathogen Interactions During Mycobacterium tuberculosis infections / Sarah A. Stanley and Jeffery S. Cox
Summary Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts
Subject Mycobacterium tuberculosis.
Host-Pathogen Interactions.
Mycobacterium tuberculosis -- metabolism.
Mycobacterium tuberculosis -- pathogenicity.
Form Electronic book
Author McKinney, John D.
Pieters, Jean (Professor of Biochemistry)
ISBN 9783642402326 (electronic bk.)
3642402321 (electronic bk.)