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E-book

Title Myelin repair and neuroprotection in multiple sclerosis / Ian D. Duncan, Robin J.M. Franklin, editors
Published New York : Springer, ©2013

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Description 1 online resource : illustrations (some color)
Contents Development of Oligodendrocytes in the Vertebrate CNS / Robert H. Miller -- Demyelination and Remyelination in Multiple Sclerosis / Lars Bø, Margaret Esiri, Nikos Evangelou and Tanja Kuhlmann -- Microglial Function in MS Pathology / Trevor J. Kilpatrick and Vilija G. Jokubaitis -- Endogenous Remyelination in the CNS / Robin J.M. Franklin, Chao Zhao, Catherine Lubetzki and Charles ffrench-Constant -- Exogenous Cell Myelin Repair and Neuroprotection in Multiple Sclerosis / Ian D. Duncan and Yoichi Kondo -- A Peripheral Alternative to Central Nervous System Myelin Repair / V. Zujovic and A. Baron Van Evercooren -- Immune Modulation and Repair Following Neural Stem Cell Transplantation / Tamir Ben-Hur, Stefano Pluchino and Gianvito Martino -- Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis / Joel A. Black, Kenneth J. Smith and Stephen G. Waxman -- Effects of Current Medical Therapies on Reparative and Neuroprotective Functions in Multiple Sclerosis / Jack P. Antel and Veronique E. Miron -- Imaging of Demyelination and Remyelination in Multiple Sclerosis / Douglas L. Arnold, Catherine M. Dalton, Klaus Schmierer, G. Bruce Pike and David H. Miller -- Designing Clinical Trials to Test Neuroprotective Therapies in Multiple Sclerosis / P. Connick, M. Kolappan, A. Compston and S. Chandran
Summary Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease.  The cause remains elusive, preventing breakthroughs in its prevention.  The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches.  However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources.  Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier.  Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients. Â
Analysis Medicine
Neurosciences
Neurology
Neurobiology
Biomedicine
Bibliography Includes bibliographical references and index
Subject Multiple sclerosis -- Treatment
Multiple Sclerosis -- physiopathology
Multiple Sclerosis -- therapy
Myelin Sheath -- pathology
HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
MEDICAL -- Neurology.
Multiple sclerosis -- Treatment
Form Electronic book
Author Duncan, I. D. (Ian Douglas), 1943-
Franklin, Robin J. M
ISBN 9781461422181
1461422183
1461422175
9781461422174
1283613174
9781283613170