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Myelin-Oligodendrocyte Glycoprotein -- See Also Multiple Sclerosis


An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
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Myelin proteins -- See Also the narrower term Myelin basic protein


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Myelin proteins. : Neuropsychiatric symptoms of inflammatory demyelinating diseases / Bruno Brochet, editor  2015 1
Myelin Proteins -- genetics. : Myelin biology and disorders / Robert A. Lazzarini  2004 1
  Myelin sheath -- 3 Related Subjects   3
Myelin Sheath.   5
  Myelin sheath Diseases -- 2 Related Subjects   2
Myelin sheath -- Diseases.   3
Myelin sheath -- Diseases -- Animal models. : Myelin biology and disorders / Robert A. Lazzarini  2004 1
Myelin sheath -- Diseases -- Atlases. : A colour atlas of multiple sclerosis & other myelin disorders / C.W.M. Adams  1989 1
Myelin sheath -- Diseases -- Magnetic resonance imaging. : Magnetic resonance of myelination and myelin disorders / Marjo S. van der Knaap, Jaap Valk ; with contributions by F. Barkhof [and others]  2005 1
Myelin sheath -- Diseases -- Periodicals : Multiple sclerosis (Houndmills, Basingstoke, England : Online)  1999 1
 

Myelin sheath formation -- See Myelination


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Myelin Sheath -- pathology. : Myelin repair and neuroprotection in multiple sclerosis / Ian D. Duncan, Robin J.M. Franklin, editors  2013 1
Myelin sheath -- Pathophysiology. : Myelin biology and disorders / Robert A. Lazzarini  2004 1
Myelin Sheath -- physiology.   3
 

Myelin Sheaths -- See Myelin Sheath


The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem
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Myelinated Nerve Fiber -- See Nerve Fibers, Myelinated


A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves
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Myelinated Nerve Fibers -- See Nerve Fibers, Myelinated


A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves
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Myelinated neurofibrils.   3
  Myelination -- 2 Related Subjects   2
Myelination.   4
 

Myelinization -- See Myelination


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Myelinoclasia -- See Encephalomyelitis


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Myelinogenesis -- See Myelination


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Myelitis -- See Also the narrower term Poliomyelitis


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Myelitis -- Patients -- Biography. : "Who borrowed my legs?" / Russell Gehling  2002 1
 

Myelitis, Transverse -- See Also Multiple Sclerosis


An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
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Myeloblastic Leukemia, Acute -- See Leukemia, Myeloid, Acute


Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES
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Myeloblastic Leukemias, Acute -- See Leukemia, Myeloid, Acute


Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES
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Myeloblastin -- See Also Granulomatosis with Polyangiitis


A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN
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Myelocele -- See Meningomyelocele


Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)
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Myeloceles -- See Meningomyelocele


Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)
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  Myelocytic Leukemia -- 2 Related Subjects   2
 

Myelocytic Leukemia, Acute -- See Leukemia, Myeloid, Acute


Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES
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Myelocytic Leukemia, Chronic -- See Leukemia, Myelogenous, Chronic, BCR-ABL Positive


Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS
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Myelocytic Leukemias -- See Leukemia, Myeloid


Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites
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Myelocytic Leukemias, Acute -- See Leukemia, Myeloid, Acute


Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES
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Myelocytic Leukemias, Chronic -- See Leukemia, Myelogenous, Chronic, BCR-ABL Positive


Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS
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Myelodysplasia, Hematopoetic -- See Myelodysplastic Syndromes


Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA
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Myelodysplasia, Spinal Cord -- See Neural Tube Defects


Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
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Myelodysplasias, Hematopoetic -- See Myelodysplastic Syndromes


Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA
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Myelodysplasias, Spinal Cord -- See Neural Tube Defects


Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
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Myelodysplastic-Myeloproliferative Disease -- See Myelodysplastic-Myeloproliferative Diseases


Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS
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Myelodysplastic-Myeloproliferative Diseases. : Myeloproliferative neoplasms : biology and therapy / edited by Srdan Verstovsek, Ayalew Tefferi  2011 1
Myelodysplastic-Myeloproliferative Diseases -- therapy. : Myeloproliferative neoplasms : biology and therapy / edited by Srdan Verstovsek, Ayalew Tefferi  2011 1
 

Myelodysplastic Syndrome -- See Myelodysplastic Syndromes


Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA
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Myelodysplastic syndromes -- See Also the narrower term Paroxysmal hemoglobinuria


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Myelodysplastic syndromes.   10
Myelodysplastic syndromes -- Diagnosis.   2
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