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E-book

Title Cancer and inflammation mechanisms : chemical, biological, and clinical aspects / edited by Dr. Yusuke Hiraku, Dr. Shosuke Kawanishi, Dr. Hiroshi Ohshima
Published Hoboken, New Jersey : Wiley, [2014]
©2014

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Description 1 online resource (xvi, 383 pages) : illustrations
Contents Titlepage; Copyright; Contents; CONTRIBUTORS; PREFACE; CHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW; INFECTION, INFLAMMATION, AND CANCER: POSSIBLE MECHANISMS; PRODUCTION OF INFLAMMATORY MEDIATORS AND REACTIVE OXIDANTS; DNA AND PROTEIN DAMAGE BY ROSs AND RNSs; INFLAMMATION, EPIGENETIC MODIFICATION, AND microRNA; CONCLUDING REMARKS; REFERENCES; CHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER; CHRONIC INFLAMMATION AND CANCER; CANCER STEM CELLS; CARCINOGENIC FACTORS ARISING FROM CHRONIC INFLAMMATION; CHRONIC INFLAMMATION AND NORMAL STEM CELL FUNCTION
Inflammation and the development and regulation of cancer stem cellsconcluding remarks; references; chapter 3 epithelial-mesenchymal transition: a link between cancer and inflammation; emt: a link between cancer and inflammation; q1: how are emt-permissive, inflammatory tumor microenvironments created?; q2: which emt-promoting signals are provided by inflammatory tumor microenvironments?; q3: how do emt-promoting signals influence the migratory behavior of tumor cells?; conclusions and future prospects; references; chapter 4 role of nitrative dna damage in inflammation- related carcinogenesis
Dna damage during chronic inflammationliver fluke-induced cholangiocarcinoma; hpv-induced cervical cancer; ebv-induced nasopharyngeal carcinoma; dna damage induced by asbestos exposure; dna damage induced by carbon nanotube; soft tissue tumors and prognosis of tumor patients; conclusions and future prospects; references; chapter 5 lipid peroxidation-derived dna adducts and the role in inflammation-related carcinogenesis; lpo-derived reactive products contribute to dna damage; results and discussion; conclusions and future prospects; references
CHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMAN TISSUESLEVEL OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS IN HUMAN TISSUES; BIOLOGICAL PROPERTIES OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS; INFLAMMATION AND FORMATION OF 4-ONE; CONCLUDING REMARKS; REFERENCES; CHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER; TLRs AND THEIR LIGANDS; TLR SIGNALING; MYD88-DEPENDENT SIGNALING PATHWAYS; TRIF-DEPENDENT SIGNALING PATHWAYS; INNATE IMMUNE CELLS IN CANCER TISSUES; TLRs AND TUMOR MICROENVIRONMENT; TOLL-LIKE RECEPTORS IN CANCER AND TUMOR THERAPY; ANTITUMOR ACTIVITY OF TLR LIGANDS
ROLES OF TLRs IN CANCER PROGRESSIONCURRENT AND FUTURE DEVELOPMENTS; REFERENCES; CHAPTER 8 INFLAMMASOMES AND INFLAMMATION; NOD-LIKE RECEPTORS AND THE INFLAMMASOMES; THE NLRP3 INFLAMMASOME; THE IPAF INFLAMMASOME; THE NLRP1 INFLAMMASOME; THE NLRP12 INFLAMMASOME; THE NLRP7 INFLAMMASOME; THE NLRP6 INFLAMMASOME; THE AIM2 INFLAMMASOME; CYTOKINE TARGETS OF THE INFLAMMASOME; INFLAMMASOME DYSREGULATION IN DISEASE; CONCLUDING REMARKS; REFERENCES; CHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSIC GENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT
Summary A new perspective on the link between inflammation and cancer Inflammation is the human body's normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Carcinogenesis.
Inflammation -- Mediators.
Inflammation -- Immunological aspects.
Cancer -- Immunological aspects.
Neoplasms -- etiology
Inflammation -- physiopathology
Inflammation Mediators
Carcinogenesis
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cancer -- Immunological aspects
Carcinogenesis
Inflammation -- Immunological aspects
Inflammation -- Mediators
Form Electronic book
Author Hiraku, Yūsuke, editor
Kawanishi, Shōsuke, 1942- editor.
Ōshima, Hiroshi, 1949- editor.
LC no. 2013039801
ISBN 9781118826553
1118826558
9781118826676
1118826671
9781118826621
1118826620
9781306533058
1306533058