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Title The tumor microenvironment / Rebecca G. Bagley, editor
Published New York : Springer, [2010]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (xviii, 767 pages) : illustrations (some color)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Combination strategies targeting hypoxia inducible factor 1 (HIF-1) for cancer therapy -- The tumor microenvironment: new insights into regulation of tumor pH by carbonic anhydrases -- Hypoxia, gene expression, and metastasis -- Molecular mechanisms regulating expression and function of cancer-associated carbonic anhydrase IX -- Glycolytic pathway as a target for tumor inhibition -- Aberrant DNA methylation in cancer cells -- DNA repair and redox signalling -- Cancer stem cells and microenvironment -- Epithelial-mesenchymal transition in development and diseases -- Invasion and metastasis -- Dormancy of disseminated tumor cells: reciprocal crosstalk with the microenvironment -- Impact of endothelial progenitor cells on tumor angiogenesis and outcome of antiangiogenic therapy: new perspectives on an ongoing controversy -- Bone marrow derived mesenchymal stem/stromal cells and tumor growth -- Integrin singaling in lymphangiogenesis -- Roles of pericytes in resistance to antiangiogenic therapy -- Tumour-promoting stromal myofibroblasts in human carcinomas -- Mast cells and tumor microenvironment -- Macrophages in the tumor microenvironment -- The prognostic significance of tumor-infiltrating lymphycytes -- The pro-inflammatory milieu and its role in malignant epithelial initiation -- Natural killer cells for adoptive immunotherapy -- Fibronectin -- Collagen in cancer -- Integrins and cancer -- Matrix metalloproteinases and cancer cell invasion/metastasis -- Tetraspanins and cancer metastasis -- Chemokines and metastasis -- Transforming growth factor-ß in lung cancer, carcinogenesis and metastasis -- Cooperative interactions between integrins and growth factor signalling in pathological angiogenesis -- The extracellular matrix and the growth and survival of tumors -- Secreted growth factors as therapeutic targets -- Adrenomedullin
Summary This book will explore the many biological and physical aspects of the tumor microenvironment. The book will include chapters on the various cells that influence tumor growth and function as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters will describe endothelial cells and pericytes that form tumor vasculature. Insights on the role of progenitor and stem cells will be included. The contribution of the supporting stroma will be addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters will describe
Bibliography Includes bibliographical references and index
Subject Tumors -- Metabolism.
Cancer cells -- Growth.
Tumors -- Physiology, Pathological
Carcinogenesis -- Molecular aspects.
Tumors -- Growth.
Neoplasms -- genetics.
Neoplasms -- pathology.
Neoplastic Processes.
Neoplastic Stem Cells -- pathology.
Neoplasm Micrometastasis -- physiopathology.
Tumor Microenvironment.
Angiogenesis Inhibitors -- therapeutic use.
Drug Discovery.
Neoplasms -- drug therapy.
Form Electronic book
Author Bagley, Rebecca G.
ISBN 9781441966155 (electronic bk.)
1441966153 (electronic bk.)