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Title Glutamate-related biomarkers in drug development for disorders of the nervous system : workshop summary / Diana E. Pankevich, Miriam Davis, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Published Washington, D.C. : National Academies Press, [2011]
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Description 1 online resource (xii, 61 pages) : illustrations (some color)
Contents Introduction -- Overview of the Glutamatergic System -- Glutamate Biomarkers -- Treatment Implications of Biomarkers -- Challenges and Opportunities -- Appendix A: References -- Appendix B: Registered Attendees -- Appendix C: Agenda
Summary Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop
Bibliography Includes bibliographical references (pages 39-43)
Notes Print version record
Subject Biochemical markers -- Congresses.
Drug development -- Congresses.
Nervous system -- Diseases -- Congresses.
Neuropharmacology -- Congresses.
Biomarkers, Pharmacological.
Central Nervous System Diseases -- diagnosis.
Central Nervous System -- drug effects.
Drug Discovery.
Glutamic Acid -- adverse effects.
Neuropharmacology -- methods.
Genre/Form Congress.
Conference papers and proceedings.
Conference papers and proceedings.
Form Electronic book
Author Altevogt, Bruce M.
Davis, Miriam (Medical writer)
Pankevich, Diana E., 1975-
Institute of Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders.
ISBN 0309212227 (electronic bk.)
9780309212229 (electronic bk.)