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Title Animal models of acute neurological injury / Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors
Edition Second edition
Published Cham, Switzerland : Springer, [2019]
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Description 1 online resource
Series Springer series in translational stroke research
Springer series in translational stroke research
Contents Intro; Preface; Contents; Part I: Animal Care and Surgery; Animal Protocol; Regulatory Oversight; Designing the Animal Protocol; Writing the Animal Protocol; References; Anesthesia and Analgesia for Research Animals; Introduction; Pre-anesthetic Considerations and Monitoring; Injectable Anesthetics; Bartiturates; Ketamine; Propofol; Sedative/Tranquilizers; Local Anesthetics; Gaseous Agents; Isoflurane; Sevoflurane; Other Inhalants; Hypothermia; Analgesia; Opioids; Non-steroidal Anti-inflammatory Drugs (NSAIDs); Other Analgesics
Airway Management in the Rodent ModelIntubation; Materials; Procedures; Transcardiac Perfusion and Fixation; Equipment and Materials; Step by Step Procedures; Methods of Brain Removal; Materials; Procedures; Brain Removal; Separation of the Brain into Anatomical Sections; Materials; Procedure; Preparation of Brain Slices for Triphenyltetrazolium Chloride Staining; Materials; Procedure; References; Brain Monitoring; Introduction; Model Selection; Materials; Intravenous Femoral Catheter; Procedure; Burr Hole and Brain Monitoring; Postoperative Care; Conclusion; References
Placement of Occluding Device Around Carotid ArteryElectrocauterization of Vertebral Artery; Occlusion of Bilateral Common Carotid Arteries; One-Day 4-VO Model (with ID Recording); Surgical Preparation; ID Recording; Outcome Evaluation; Ischemic Cell Death in the Hippocampus; Ischemic Cell Death in the Striatum; Advantages, Complications and Limitations; Advantages; Complications; Limitations; Technical Difficulties; Mortality; Variation; References; Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia; Introduction
Special Considerations-Anesthesia and Analgesia for Animal Models of Neurologic DiseasesCerebral Ischemia and Hemorrhage Models; Physiologic Effects of Anesthesia and the Impact on Cerebral Ischemia and Hemorrhage Models; Anesthetic Considerations; Analgesic Considerations; Traumatic Brain Injury Models; Anesthetic Considerations; Analgesic Considerations; Spinal Cord Injury Models; Physiologic Effects of Anesthesia and the Impact on SCI Models; Anesthetic and Analgesic Agents Impact Spinal Injury Models; References; Rodent Surgical Procedures and Tissue Collection; Introduction
Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An UpdateModel Selection; Materials and Methods; Before Surgery and SCI; Surgery and SCI; Sterilization; Preparation; Surgery and SCI; Acutely and the First Week After Surgery and SCI; Housing; Veterinary Care; Chronically After Surgery and SCI; References; Part II: Cerebral Ischemic Animal Models; Four-Vessel Occlusion Model in Rats; Model Selection; Materials; Animal; Anesthesia; Equipment; Anesthesia; Surgery; Recording of Ischemic Depolarization; Procedures; Original 4-VO Model
Summary Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The books focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field
Notes Includes index
Online resource; title from digital title page (viewed on September 13, 2019)
Subject Nervous system -- Diseases -- Animal models -- Handbooks, manuals, etc
Nervous system -- Pathophysiology -- Animal models -- Handbooks, manuals, etc
Nervous system -- Wounds and injuries -- Handbooks, manuals, etc
Nervous system -- Diseases -- Animal models.
Nervous system -- Wounds and injuries.
Genre/Form Handbooks and manuals.
Form Electronic book
Author Chen, Jun, editor
Xu, Xiao-Ming, editor
Xu, Zao C., editor
Zhang, J. H. (John H.), editor
ISBN 3030160823
9783030160821