| Description |
1 online resource : illustrations (some color) |
| Contents |
Intro; Foreword; Preface; Contents; Part I: Pathology and Pathobiology; 1: Pathology and  Immunohistochemistry in Thyroid Tumors; 1.1 Introduction; 1.2 Immunochemistry in Follicular-Derived Tumors; 1.3 Immunomarkers of  Malignancy; 1.4 Prognostic and  Predictive Markers; 1.5 Antibodies Directed Against Mutated Genes; References; 2: Pathology of  Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and  Circulating Molecular Markers; 2.1 Introduction; 2.2 Nomenclature and  Classification; 2.2.1 Nomenclature; 2.2.2 Classification of  Neuroendocrine Neoplasms |
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2.2.2.1 GEP System2.2.2.2 Pulmonary System; 2.3 Morphological Aspects; 2.3.1 Cytological Features; 2.3.1.1 Well-Differentiated Neuroendocrine Neoplasms (Typical Carcinoids, Atypical Carcinoids, Well-Differentiated Neuroendocrine Tumors); 2.3.1.2 Poorly Differentiated Neuroendocrine Carcinomas (NEC) (Large Cell and  Small Cell Types); 2.3.2 Histological Features; 2.4 Immunohistochemical Markers; 2.4.1 General Neuroendocrine Markers; 2.4.1.1 Chromogranin A; 2.4.1.2 Synaptophysin; 2.4.1.3 Other Markers |
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Neuron-Specific Enolase and  Other Enzymes Involved in Hormone Synthesis and  MetabolismSurface Antigens; Achaete-Scute Homologue 1; 2.4.2 Epithelial Markers; 2.4.3 Markers for Proliferation: Ki67; 2.4.4 Site-Specific Markers; 2.4.4.1 Well-Differentiated NETs; Transcription Factors; Caudal Type Homeobox 2 (CDX2); Thyroid Transcription Factor-1 (TTF-1); Paired Box Gene 8 (PAX8); Insulin Gene Enhancer Binding Protein Isl-1 (Islet 1); Pancreatic and  Duodenal Homeobox 1 (PDX1); Amine and  Peptide Hormones; 2.4.4.2 Poorly Differentiated NECs |
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2.4.5 Prognostic and  Predictive (Theranostic) Markers2.4.5.1 Somatostatin Receptors; 2.4.5.2 Cytokeratin 19; 2.4.5.3 CD117; 2.4.5.4 Mismatch Repair Proteins; 2.5 Practical Applications of  Immunohistochemistry in Routine Diagnosis; 2.5.1 Cytology; 2.5.2 Histology; 2.6 Circulating Molecular Markers; References; 3: Circulating Biomarkers: Biological Basis, Methods, and  Interpretation Criteria; 3.1 Biological Basis and  Use of  Biomarkers; 3.2 Methods and  Quality Requirements for Biomarkers; 3.3 Clinical Performance of  Biomarkers; 3.4 Monitoring Cancer Disease by Biomarkers |
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3.5 Biomarkers in Neuroendocrine Tumors (NETs)3.6 Diagnostic Performance of  Monoanalytes in NETs; 3.7 Perspective: Multianalyte Approaches; References; Part II: Differentiated Thyroid Cancer; 4: Differentiated Thyroid Cancer: Diagnosis, Therapy, and  Follow-Up; 4.1 Introduction; 4.2 Epidemiology and  Clinical Behavior; 4.2.1 Incidence; 4.2.2 Histology and  Clinical Behavior; 4.2.2.1 Papillary Thyroid Carcinoma; 4.2.2.2 Follicular Thyroid Carcinoma; 4.3 Diagnosis; 4.3.1 Presentation; 4.3.2 Ultrasound; 4.3.3 Scintigraphy; 4.3.4 Fine Needle Aspiration Biopsy; 4.4 Treatment |
| Summary |
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed January 31, 2018) |
| Subject |
Thyroid gland -- Tumors.
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Neuroendocrine tumors.
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Tumor markers.
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Pathology.
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Thyroid Neoplasms -- diagnosis
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Biomarkers, Tumor
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Neuroendocrine Tumors -- diagnosis
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Thyroid Neoplasms -- therapy
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Neuroendocrine Tumors -- therapy
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Pathology
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pathology.
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Medical laboratory testing & techniques.
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Nuclear medicine.
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Radiotherapy.
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Pathology.
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Endocrinology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Neuroendocrine tumors
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Thyroid gland -- Tumors
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Tumor markers
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| Form |
Electronic book
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| Author |
Giovanella, Luca, editor.
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| LC no. |
2017964409 |
| ISBN |
9783319625065 |
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3319625063 |
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