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E-book
Author Crawley, Jacqueline N.

Title What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice / Jacqueline N. Crawley
Edition Second edition
Published Hoboken, N.J. : Wiley-Interscience, [2007]
©2007
Online access available from:
Wiley Online Books    View Resource Record  
ProQuest Ebook Central (Limited concurrent users)    View Resource Record  

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Description 1 online resource (xvi, 523 pages) : illustrations
Contents Designer mice : scope and sourcebooks -- Of unicorns and chimeras : how to generate a transgenic or knockout mouse for behavioral phenotyping -- General health : give your mouse a physical -- Motor functions : open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures -- Sensory abilities : olfaction, vision, hearing, taste, touch, nociception -- Learning and memory : Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention -- Feeding and drinking : daily consumption, restricted access, choice tests, microstructural analysis -- Reproductive behaviors : sexual and parental behaviors -- Social behaviors : social interaction, nesting, grooming, juvenile play, aggression -- Emotional behaviors : animal models of psychiatric disorders : mouse models of fear, anxiety, depression, schizophrenia -- Reward : self-administration of addictive drugs, conditioned place preference -- Neurodevelopment and neurodegeneration : assaying behaviours in infant, juvenile, and aged mice -- Putting it all together : choice of tests, order of testing, number of mice, equipment, housing and testing environment -- The next generation : conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues
Summary This new edition of Whats Wrong With My Mouse? continues to provide the most thorough overview of mutant mouse technology and a readable introduction to the field of behavioural neuroscience as applied to behavioural phenotyping of transgenic and knockout mice
Bibliography Includes bibliographical references (pages 383-501) and index
Notes Print version record
Subject Neurogenetics -- Animal models.
Transgenic mice -- Behavior.
Behavior, Animal.
Disease Models, Animal.
Genetics, Behavioral -- methods.
Mice, Knockout.
Mice, Transgenic.
Phenotype.
Form Electronic book
Author Wiley InterScience (Online service)
ISBN 0470119047
0470119055
0471471925 (cloth)
9780470119044
9780470119051
9780471471929 (cloth)