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Title Atlas of thyroid and neuroendocrine tumor markers / Luca Giovanella, editor
Published Cham : Springer, [2018]
Online access available from:
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Description 1 online resource : illustrations (some color)
Contents Intro; Foreword; Preface; Contents; Part I: Pathology and Pathobiology; 1: Pathology and Immunohistochemistry in Thyroid Tumors; 1.1 Introduction; 1.2 Immunochemistry in Follicular-Derived Tumors; 1.3 Immunomarkers of Malignancy; 1.4 Prognostic and Predictive Markers; 1.5 Antibodies Directed Against Mutated Genes; References; 2: Pathology of Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and Circulating Molecular Markers; 2.1 Introduction; 2.2 Nomenclature and Classification; 2.2.1 Nomenclature; 2.2.2 Classification of Neuroendocrine Neoplasms GEP System2.2.2.2 Pulmonary System; 2.3 Morphological Aspects; 2.3.1 Cytological Features; Well-Differentiated Neuroendocrine Neoplasms (Typical Carcinoids, Atypical Carcinoids, Well-Differentiated Neuroendocrine Tumors); Poorly Differentiated Neuroendocrine Carcinomas (NEC) (Large Cell and Small Cell Types); 2.3.2 Histological Features; 2.4 Immunohistochemical Markers; 2.4.1 General Neuroendocrine Markers; Chromogranin A; Synaptophysin; Other Markers
2.4.5 Prognostic and Predictive (Theranostic) Markers2.4.5.1 Somatostatin Receptors; Cytokeratin 19; CD117; Mismatch Repair Proteins; 2.5 Practical Applications of Immunohistochemistry in Routine Diagnosis; 2.5.1 Cytology; 2.5.2 Histology; 2.6 Circulating Molecular Markers; References; 3: Circulating Biomarkers: Biological Basis, Methods, and Interpretation Criteria; 3.1 Biological Basis and Use of Biomarkers; 3.2 Methods and Quality Requirements for Biomarkers; 3.3 Clinical Performance of Biomarkers; 3.4 Monitoring Cancer Disease by Biomarkers
3.5 Biomarkers in Neuroendocrine Tumors (NETs)3.6 Diagnostic Performance of Monoanalytes in NETs; 3.7 Perspective: Multianalyte Approaches; References; Part II: Differentiated Thyroid Cancer; 4: Differentiated Thyroid Cancer: Diagnosis, Therapy, and Follow-Up; 4.1 Introduction; 4.2 Epidemiology and Clinical Behavior; 4.2.1 Incidence; 4.2.2 Histology and Clinical Behavior; Papillary Thyroid Carcinoma; Follicular Thyroid Carcinoma; 4.3 Diagnosis; 4.3.1 Presentation; 4.3.2 Ultrasound; 4.3.3 Scintigraphy; 4.3.4 Fine Needle Aspiration Biopsy; 4.4 Treatment
Neuron-Specific Enolase and Other Enzymes Involved in Hormone Synthesis and MetabolismSurface Antigens; Achaete-Scute Homologue 1; 2.4.2 Epithelial Markers; 2.4.3 Markers for Proliferation: Ki67; 2.4.4 Site-Specific Markers; Well-Differentiated NETs; Transcription Factors; Caudal Type Homeobox 2 (CDX2); Thyroid Transcription Factor-1 (TTF-1); Paired Box Gene 8 (PAX8); Insulin Gene Enhancer Binding Protein Isl-1 (Islet 1); Pancreatic and Duodenal Homeobox 1 (PDX1); Amine and Peptide Hormones; Poorly Differentiated NECs
Summary This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments
Bibliography Includes bibliographical references
Subject Biomarkers, Tumor.
Thyroid Neoplasms -- diagnosis.
Neuroendocrine Tumors -- diagnosis.
Neuroendocrine Tumors -- therapy.
Thyroid Neoplasms -- therapy.
Neuroendocrine tumors.
Thyroid gland -- Tumors.
Tumor markers.
Form Electronic book
Author Giovanella, Luca, editor
ISBN 3319625063 (electronic bk.)
9783319625065 (electronic bk.)