| Description |
1 online resource (379 pages) |
| Contents |
Cover -- Half Title -- Title -- Copyright -- Dedication -- Brief Contents -- Detailed Contents -- List of Boxes -- Author Biography -- Preface -- Chapter 1 An Introduction to the Field of Developmental Neurobiology -- Cellular Structures and Anatomical Regions of the Nervous System -- The Central and Peripheral Nervous Systems Are Comprised of Neurons and Glia -- The Nervous System Is Organized around Three Axes -- Origins of CNS and PNS Regions -- The Vertebrate Neural Plate Gives Rise to Central and Peripheral Structures -- Future Vertebrate CNS Regions Are Identified at Early Stages of Neural Development -- The Timing of Developmental Events Is Standardized in Many Vertebrates -- Anatomical Regions and the Timing of Developmental Events Are Mapped in Invertebrate Nervous Systems -- The Drosophila CNS and PNS Arise from Distinct Areas of Ectoderm -- Cell Lineages Can Be Mapped in C. Elegans -- Gene Regulation in the Developing Nervous System -- Experimental Techniques Are Used to Label Genes and Proteins in the Developing Nervous System -- Altering Development Helps Understand Normal Processes -- Using Naturally Occurring Events to Understand Neural Development -- Summary -- Further Reading -- Chapter 2 Neural Induction -- Neural Tissue is Designated During Embryogenesis -- Gastrulation Creates New Cell and Tissue Interactions That Influence Neural Induction -- Neural Induction: Early Discoveries -- Amphibian Models Were Used in Early Neuroembryology Research and Remain Popular Today -- A Region of the Dorsal Blastopore Lip Organizes the Amphibian Body Axis and Induces the Formation of Neural Tissue -- The Search for the Neural Inducer Took Decades of Research -- New Tissue Culture Methods and Cell-Specific Markers Advanced the Search for Neural Inducers -- Neural Induction: The Next Phase of Discoveries |
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Studies Suggest Neural Induction Might Require Removal of Animal Cap-Derived Signals -- Mutation of the Activin Receptor Prevents the Formation of Ectoderm and Mesoderm but Induces Neural Tissue -- Modern Molecular Methods Led to the Identification of Three Neural Inducers -- Noggin, Follistatin, and Chordin Prevent Epidermal Induction -- Studies of Epidermal Induction Revealed the Mechanism for Neural Induction -- The Discovery of Neural Inducers in the Fruit Fly Drosophila Led to a New Model for Epidermal and Neural Induction -- BMP Signaling Pathways Are Regulated by SMADs -- Additional Signaling Pathways May Influence Neural Induction in Some Contexts -- Additional Neural Induction Pathways May Be Used in Some Species -- Summary -- Further Reading -- Chapter 3 Segmentation of the Anterior-Posterior Axis -- Neural Tube Formation -- Early Segmentation of the Neural Tube Establishes Subsequent Organization -- Temporal-Spatial Differences in Organizer-Derived Signals Induce Head and Tail Structures -- Activating, Transforming, and Inhibitory Signals Interact to Pattern the A/P Axis -- Specification of Forebrain Regions -- Signals from Extraembryonic Tissues Pattern Forebrain Areas -- Forebrain Segments Are Characterized by Different Patterns of Gene Expression -- Signals Prevent Wnt Activity in Forebrain Regions -- Regionalization of the Mesencephalon and Metencephalon Regions -- Intrinsic Signals Pattern the Midbrain-Anterior Hindbrain -- Multiple Signals Interact to Pattern Structures Anterior and Posterior to the Isthmus -- FGF Is Required for Development of the Cerebellum -- FGF Isoforms and Intracellular Signaling Pathways Influence Cerebellar and Midbrain Development -- FGF and Wnt Interact to Pattern the A/P Axis -- Rhombomeres: Segments of the Hindbrain -- Cells Usually Do Not Migrate between Adjacent Rhombomeres |
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Multiple Signals Interact to Regulate Krox20 and EphA4 Expression in r3 and r5 -- Hox Genes Regulate Hindbrain Segmentation -- The Body Plan of Drosophila Is a Valuable Model for Studying Segmentation Genes -- The Homeotic Genes That Establish Segment Identity Are Conserved across Species -- Transcription Factors Regulate Hox Gene Expression and Rhombomere Identity -- Retinoic Acid Regulates Hox Gene Expression -- The RA-Degrading Enzyme Cyp26 Helps Regulate Hox Gene Activity in the Hindbrain -- RA and FGF Differentially Pattern Posterior Rhombomeres and Spinal Cord -- Cdx Transcription Factors Are Needed to Regulate Hox Gene Expression in the Spinal Cord -- The Activation-Transformation Model Is Being Revised -- Summary -- Further Reading -- Chapter 4 Patterning along the Dorsal-Ventral Axis -- Anatomical Landmarks and Signaling Centers in the Posterior Vertebrate Neural Tube -- The Sulcus Limitans Is an Anatomical Landmark That Separates Sensory and Motor Regions -- Labeling Techniques Identify Cell Types along the D/V Axis -- The Roof Plate and Floor Plate Produce Signals That Influence D/V Patterning -- Roof Plate and Floor Plate Signals Influence Gene Expression Patterns along the D/V Axis of the Neural Tube -- Ventral Signals and Motor Neuron Patterning in the Posterior Neural Tube -- The Notochord Is Required to Specify Ventral Structures -- Sonic Hedgehog (Shh) Is Necessary for Floor Plate and Motor Neuron Induction -- Shh Concentration Differences Regulate Induction of Ventral Neuron Subtypes -- Genes Are Activated or Repressed by the Shh Gradient -- Shh Binds to and Regulates Patched Receptor Expression -- Shh Signals Interact to Influence Gene Expression and Ventral Patterning -- RA and FGF Signals Are Also Used in Ventral Patterning -- Dorsal Patterning in the Posterior Neural Tube |
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Cajal-Retzius Cells Release the Protein Reelin, a Stop Signal for Migrating Neurons -- Cortical Interneurons Reach Target Areas by Tangential Migration -- Cell Migration Patterns in the Cerebellum Reflect Its Distinctive Organization -- Cerebellar Neurons Arise from Two Zones of Proliferation -- Granule Cell Migration from External to Internal Layers of the Cerebellar Cortex Is Facilitated by Astrotactin and Neuregulin -- Mutant Mice Provide Clues to the Process of Neuronal Migration in the Cerebellum -- Migration in the Peripheral Nervous System: Examples From Neural Crest Cells -- Neural Crest Cells Emerge from the Neural Plate Border -- Neural Crest Cells from Different Axial Levels Contribute to Specific Cell Populations -- Cranial Neural Crest Forms Structures in the Head -- Multiple Mechanisms Are Used to Direct Neural Crest Migration -- Trunk Neural Crest Cells Are Directed by Permissive and Inhibitory Cues -- Melanocytes Take a Different Migratory Route Than Other Neural Crest Cells -- Summary -- Further Reading -- Chapter 6 Cell Determination and Early Differentiation -- Lateral Inhibition and Notch Receptor Signaling -- Lateral Inhibition Designates Future Neurons in Drosophila Neurogenic Regions -- Lateral Inhibition Designates Stripes of Neural Precursors in the Vertebrate Spinal Cord -- Cellular Determination in the Invertebrate Nervous System -- Cells of the Drosophila PNS Arise from Epidermis and Develop in Response to Differing Levels of Notch Signaling Activity -- Ganglion Mother Cells Give Rise to Drosophila CNS Neurons -- Apical and Basal Polarity Proteins Are Differentially Segregated in GMCs -- Cell Location and Temporal Transcription Factors Influence Cellular Determination -- Mechanisms Underlying Fate Determination in Vertebrate CNS Neurons -- Coordinating Signals Mediate the Progressive Development of Cerebellar Granule Cells |
| Notes |
Temporally Regulated Transcription Factor Networks Help Mediate the Fate of Cerebral Cortical Neurons |
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Description based on publisher supplied metadata and other sources |
| Subject |
Developmental neurobiology
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Neurotransmitters
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Developmental neurobiology.
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Neurotransmitters.
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| Form |
Electronic book
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| ISBN |
9781000803662 |
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100080366X |
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