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Title The multiple therapeutic targets of A20 / edited by Christiane Ferran, MD, PhD, Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and the Transplant Insitutue, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Published New York, N.Y. : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, [2014]
©2014
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Description 1 online resource (xxi, 188 pages) : illustrations (some color)
Series Advances in experimental medicine and biology ; 809
Advances in experimental medicine and biology ; v. 809
Contents A20: a bipartite ubiquitin editing enzyme with immunoregulatory potential / Ingrid Wertz and Vishva Dixit -- The biology of A20-binding inhibitors of NF- [kappa]B activation (ABINs) / Lynn Verstrepen, Isabelle Carpentier and Rudi Beyaert -- The Biology of A20-Like Molecules / Karine Enesa and Paul Evans -- Anti-viral tetris: modulation of the innate anti-viral immune response by A20 / Meztli Arguello, Suzanne Paz, Christiane Ferran, Herwig P. Moll and John Hiscott -- A20 expressing tumors and anticancer drug resistance / Cleide Gonçalves da Silva, Darlan Conterno Minussi, Christiane Ferran and Markus Bredel -- Translational studies of A20 in atherosclerosis and cardiovascular disease / Fiona C. McGillicuddy, Herwig P. Moll, Samira Farouk, Scott M. Damrauer, Christiane Ferran and Muredach P. Reilly -- A20: a biomarker of allograft outcome: a showcase in kidney transplantation / Gabor Bodonyi-Kovacs, Terry B. Strom and Prabhakar Putheti -- A20: an omnipotent protein in the liver: Prometheus myth resolved? / Cleide Gonçalves da Silva, Jesus Revuelta Cervantes, peter Studer and Christiane Ferran -- Emerging roles for A20 in islet biology and pathology / Nathan W. Zammit and Shane T. Grey -- Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases / Alessandra Mele, Jesus Revuelta Cervantes, Victor Chien, David Friedman and Christiane Ferran
Summary "This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target"--Publisher's description
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Immunoglobulin A.
Inflammation.
Anti-Inflammatory Agents -- therapeutic use.
DNA-Binding Proteins -- metabolism.
DNA-Binding Proteins -- therapeutic use.
Inflammation -- therapy.
Intracellular Signaling Peptides and Proteins -- metabolism.
Intracellular Signaling Peptides and Proteins -- therapeutic use.
NF-kappa B -- antagonists & inhibitors.
Nuclear Proteins -- metabolism.
Nuclear Proteins -- therapeutic use.
Form Electronic book
Author Ferran, Christiane, editor
ISBN 9781493903986 (electronic bk.)
1493903985 (electronic bk.)