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Title Adult craniopharyngiomas differences and lessons from paediatrics / Emmanuel Jouanneau, Gérald Raverot, editors
Published Cham : Springer, 2020
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Description 1 online resource (233 p.)
Contents Intro -- Foreword 1 -- Foreword 2 -- Acknowledgement -- Contents -- 1: Histopathology and Molecular Pathology of Craniopharyngioma in Adults -- 1.1 Introduction -- 1.2 Adamantinomatous Craniopharyngioma -- 1.2.1 Histopathology -- 1.2.1.1 Histopathological Features -- 1.2.1.2 Regressive Changes and Surrounding Nervous Tissue -- 1.2.2 Molecular Pathology -- 1.2.3 ACP and Odontogenesis -- 1.3 Papillary Craniopharyngioma -- 1.3.1 Histopathology -- 1.3.2 Molecular Pathology -- 1.3.3 Origin of PCP -- 1.4 Mixed and Collision Tumors -- 1.5 Malignant Transformation in Craniopharyngiomas
1.6 Differential Diagnosis -- 1.6.1 ACP and Pilocytic Astrocytoma -- 1.6.2 PCP and Rathke's Cleft Cyst with Squamous Metaplasia -- 1.6.3 ACP and Sellar Xanthogranuloma -- 1.6.4 ACP Versus PCP -- 1.6.5 Cystic ACP and Rathke's Cleft Cysts -- 1.7 Conclusion -- References -- 2: Mouse Models of Craniopharyngioma -- 2.1 Genetically Engineered Mouse Models (GEMMS) of Craniopharyngioma -- 2.1.1 Adamantinomatous Craniopharyngioma -- 2.1.2 Embryonic Model of Human ACP -- 2.1.3 Inducible Model of Human ACP
2.2 Stem Cell Paracrine Tumourigenesis: A Novel Mechanism of Somatic Stem Cells Contribution to Tumour Formation -- 2.3 Childhood-Onset Craniopharyngioma is a Developmental Disorder -- 2.4 Cluster Cells Are Molecularly Similar and Share a Signature of Cellular Senescence -- 2.5 Papillary Craniopharyngioma and Adamantinomatous Craniopharyngioma are Distinct Tumour Entities -- 2.6 Patient-Derived Xenografts (PDXs) Models of Human Craniopharyngioma -- 2.7 Therapeutic Lessons from Mouse Models -- 2.8 Conclusion -- References
3.4 Long-Term Morbidity and Mortality in Treated Adult-Onset CP -- 3.4.1 Morbidity -- 3.4.1.1 Endocrine Morbidity -- 3.4.1.2 Ophthalmologic Morbidity -- 3.4.1.3 Hypothalamic Morbidity -- 3.4.2 Mortality -- 3.5 Modern Management of CP Improves Prognosis? -- 3.6 Conclusion -- References -- 4: Craniopharyngioma Diagnosis: A Rationale for Accurate MRI Assessment of Tumor Topography and Adhesion to the Hypothalamus -- 4.1 Introduction. MRI Assessment of Craniopharyngiomas: What Essential Information Should a Neurosurgeon Obtain from It?
3: Epidemiology, Clinical Presentation, and Prognosis of Adult-Onset Craniopharyngioma -- 3.1 History -- 3.2 Epidemiology of Adult-Onset CP -- 3.3 Clinical Presentation of Adult-Onset Craniopharyngioma -- 3.3.1 Our series (Table 3.1) -- 3.3.1.1 Ophthalmology -- 3.3.1.2 Endocrine Symptoms -- 3.3.1.3 Non-specific Symptoms -- 3.3.1.4 Hypothalamic and Limbic Symptoms -- 3.3.1.5 Radiology and Histology -- 3.3.2 Literature -- 3.3.2.1 Ophthalmology -- 3.3.2.2 Endocrine -- 3.3.2.3 Hypothalamic and Limbic Symptoms -- 3.3.2.4 Other Symptoms
Summary This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists
Notes 4.2 Radiological Diagnosis of Craniopharyngiomas: Historical Development
Description based upon print version of record
Includes index
Subject Brain -- Tumors -- Surgery
Brain -- Tumors -- Treatment
Craniopharyngioma.
Brain -- Tumors -- Surgery.
Brain -- Tumors -- Treatment.
Endocrinology.
Medical -- Biochemistry.
Medical -- Endocrinology & Metabolism.
Medical -- Oncology.
Medical -- Pediatrics.
Medical -- Surgery -- Neurosurgery.
Neurosurgery.
Oncology.
Paediatric medicine.
Radiology.
Form Electronic book
Author Jouanneau, Emmanuel
Raverot, Gérald
ISBN 3030411761
303041177X
3030411788
9783030411763
9783030411770
9783030411787