An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS)
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
Peripherer Raum : Peripheralization : the making of spatial dependencies and social injustice / Andrea Fischer-Tahir, Matthias Naumann (eds.)
2013
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Peripheres Gerät : Collaborative assistive robot for mobility enhancement (CARMEN) : the bare necessities: assisted wheelchair navigation and beyond / Cristina Urdiales ; [co-authors: José Manuel Peula Palacios, Manuel Fdez-Carmona]
English language -- Periphrasis. : Modals and periphrastics in English : an investigation into the semantic correspondence between certain English modal verbs and their periphrastic equivalents / Paul Westney
1995
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Romance languages -- Periphrasis : Periphrasis and inflexion in diachrony : a view from romance / edited by Adam Ledgeway, John Charles Smith, Nigel Vincent
2022
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Spanish language -- Periphrasis : La gramática en la diacronía : la evolución de las perífrasis verbales modales en español / Mar Garachana Camarero (ed.)
