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Title BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease / edited by Varghese John
Published Hoboken, N.J. : John Wiley & Sons, [2010]
Online access available from:
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Description 1 online resource (1 electronic resource (xvi, 250 pages, 16 unnumbered pages of plates)) : illustrations (some color)
Contents BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others]
Summary BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Alzheimer's disease -- Chemotherapy.
Amyloid beta-protein precursor.
Aspartic proteinases -- Inhibitors -- Therapeutic use.
Alzheimer Disease -- drug therapy.
Amyloid Precursor Protein Secretases -- pharmacology.
Amyloid Precursor Protein Secretases -- therapeutic use.
Form Electronic book
Author John, Varghese, 1958-
Wiley InterScience (Online service)
LC no. 2009037093
ISBN 047029342X (cloth)
0470594071 (electronic bk.)
9780470293423 (cloth)
9780470594070 (electronic bk.)
Other Titles Beta-site APP Cleaving Enzyme