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Book Cover
E-book

Title Modern anesthetics / Jürgen Schüttler, Helmut Schwilden, editors ; contributors J. Ahonen [and others]
Published Berlin : Springer, ©2008

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Description 1 online resource (xv, 498 pages) : illustrations
Series Handbook of experimental pharmacology, 0171-2004 ; 182
Handbook of experimental pharmacology ; v. 182. 0171-2004
Contents pt. I. Molecular Mechanisms of Anesthetic Action. The Site of Anesthetic Action / B.W. Urban -- Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic Actions / A. Zeller, R. Jurd, S. Lambert, M. Arras and B. Drexler, C. Grashoff, B. Antkowiak, and U. Rudolf -- Actions of Anesthetics on Excitatory Transmitter-Gated Channels / G. Akk, S. Mennerick and J.H. Steinbach -- Voltage-Gated Ion Channels / C. Nau -- G-Protein-Coupled Receptors / R.D. Sanders, D. Brian and M. Maze -- pt. II. Modern Inhalation Anesthetics. Inhalation Anaesthesia: From Diethyl Ether to Xenon / J.G. Bovill -- General Anesthetics and Long-Term Neurotoxicity / M. Perouansky -- Special Aspects of Pharmacokinetics of Inhalation Anesthesia / J.F.A. Hendrickx and A. De Wolf -- Inhalational Anaesthetics and Cardioprotection / N.C. Weber and W. Schlack -- Non-Immobilizing Inhalational Anesthetic-Like Compounds / M. Perouansky -- pt. III. Modern Intravenous Anesthetics -- Propofol / C. Vanlersberghe and F. Camu -- Pharmacokinetics and Pharmacodynamics of GPI 15715 or Fospropofol (Aquavan Injection) -- A Water-Soluble Propofol Prodrug / J. Fechner, H. Schwilden and J. Schüttler -- Etomidate and Other Non-Barbiturates / C. Vanlersberghe and F. Camu -- Remifentanil and Other Opioids / F.S. Servin and V. Billard -- Ketamine / B. Sinner and B.M. Graf -- Midazolam and Other Benzodiazepines / K.T. Olkkola and J. Ahonen -- pt. IV. Pharmacokinetics-Pharmacodynamics Based Administration of Anesthetics -- The Effect of Altered Physiological States on Intravenous Anesthetics / T.K. Henthorn -- Anesthetics Drug Pharmacodynamics / P. Bischoff, G. Schneider and E. Kochs -- Defining Depth of Anesthesia / S.L. Shafer and D.R. Stanski -- Target Controlled Anaesthetic Drug Dosing / H. Schwilden and J. Schüttler -- Advanced Technologies and Devices for Inhalational Anesthetic Drug Dosing / J.-U. Meyer, G. Kullik, N. Wruck, K. Kück and J. Manigel -- Hypnotic and Opioid Anesthetic Drug Interactions on the CNS, Focus on Response Surface Modeling / T.W. Bouillon
Summary Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient's purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled?Modern Inhalation Anesthetics? appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970's anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure.?The very mechanism of anesthetic action at the biophase? was discussed within the theoretical framework of the?u- tary theory of narcosis?
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Anesthetics.
Toxicology.
Anesthetics -- pharmacology
Anesthetics
Anesthetics, General
Toxicology
toxicology.
MEDICAL -- Pain Medicine.
MEDICAL -- Psychiatry -- Psychopharmacology.
Anesthetics.
Anesthetics -- pharmacology.
Biomédecine.
Sciences de la vie.
Anesthetics
Form Electronic book
Author Schüttler, Jürgen.
Schwilden, Helmut.
ISBN 9783540748069
3540748067
9783540728139
3540728139
9786611179397
6611179399