An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Poliomyelitis -- Prevention -- Congresses : Options for Poliomyelitis Vaccination in the United States : Workshop Summary / Vaccine Safety Forum, Division of Health Promotion and Disease Prevention
Poliomyelitis -- United States -- Prevention -- Congresses : Options for poliomyelitis vaccination in the United States : workshop summary / Vaccine Safety Forum, Division of Health Promotion and Disease Prevention, Institute of Medicine ; Cynthia J. Howe and Richard B. Johnston, editors
Poliomyelitis vaccine -- Contamination. : Immunization safety review : SV40 contamination of polio vaccine and cancer / Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention ; Kathleen Stratton, Donna A. Alamario [sic], and Marie C. McCormick, editors ; Institute of Medicine of the National Academies
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
A species of ENTEROVIRUS which is the causal agent of POLIOMYELITIS in humans. Three serotypes (strains) exist. Transmission is by the fecal-oral route, pharyngeal secretions, or mechanical vector (flies). Vaccines with both inactivated and live attenuated virus have proven effective in immunizing against the infection
