Title Pharmaceutics / Shelley Chambers Fox

Published London : Pharmaceutical Press, [2014] ©2014

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Description 1 online resource (xiv, 539 pages) : illustrations Series Remington education Remington education. Contents Cover -- Half Title -- Remington Education -- Title Page -- Copyright -- Table of Contents -- Preface -- About the author -- Acknowledgments -- 1 Introduction to dosage form design -- Introduction -- Properties of the drug -- Qualities of the ideal dosage form -- Pharmaceutical necessities -- Properties of the routes of administration -- Routes of administration -- Liberation, absorption, distribution, metabolism and elimination (LADME) -- Selected reading -- 2 Intermolecular forces and the physical and pharmaceutical properties of drugs -- Introduction -- Solid state, forces between ions and molecules, and physical properties of drugs -- Surface interactions and the pharmaceutical properties of drugs -- Solubility and dissolution -- Partitioning behavior of drug molecules: Log P -- Dissolution of solids -- Selected reading -- 3 Dispersed systems -- Introduction -- Behavior of molecular solutions, colloidal dispersions, and coarse dispersions -- Flow and viscosity -- Questions and cases -- Selected reading -- 4 Properties of solutions and manipulation of solubility -- Introduction -- Colligative properties of molecular solutions -- Manipulation of solubility -- Selected reading -- 5 Chemical stability of drugs -- Introduction -- Common pathways of drug degradation -- Small drug molecules -- Oxidation -- Photolysis -- Racemization -- Protein drug degradation -- Rates of drug degradation reactions -- Managing chemical stability problems -- Selected reading -- 6 Drug travel from dosage form to receptor -- Introduction -- Physicochemical factors -- Water solubility -- Log P -- Log D -- pH/pKa -- Molecular weight -- Biological factors -- Membrane structure and transport mechanisms -- Movement of drugs across membranes -- Blood flow, tissue perfusion, and other modes of distribution -- Tissue and plasma protein binding -- Drug metabolism (Table 6.5) Dosage form factors -- Patient factors -- Selected reading -- 7 Bioavailability, bioequivalence and the Biopharmaceutical Classification System -- Introduction -- Pharmaceutical equivalence + bioequivalence = therapeutic equivalence -- Bioavailability -- Bioequivalence of systemically available drug products -- Biopharmaceutical Classification System -- Biopharmaceutical Drug Disposition Classification System -- Selected reading -- 8 Parenteral drug delivery -- Introduction -- Characteristics of parenteral administration routes -- Parenteral dosage forms -- Preparation and handling of parenteral products -- Parenteral stability/compatibility -- Patient counseling -- Selected reading -- 9 Delivery of biopharmaceuticals and the use of novel carrier systems -- Introduction -- Physicochemical and biological properties -- Movement from administration site to target -- Design of delivery systems -- Biosimilars -- Selected reading -- 10 Drug delivery to the eye -- Introduction -- Characteristics of the ophthalmic route -- Drug properties and the eye -- Dosage forms for the ophthalmic route (Table 10.3) -- Counseling patients -- Ophthalmic ointment and gels -- Selected reading -- 11 Drug delivery to and from the oral cavity -- Introduction -- Characteristics of the oral cavity route -- Drug properties and the oral cavity -- Oral cavity dosage forms -- Counseling patients -- Selected reading -- 12 Oral delivery of immediate release dosage forma -- Introduction -- Characteristics of the gastrointestinal route -- Drug properties and the gastrointestinal route -- Immediate release dosage forms: oral liquids -- Immediate release dosage forms: oral solids -- Counseling patients -- Selected reading -- 13 Oral delivery of modified release solid dosage forms -- Introduction -- Characteristics of modified release oral solids Drug properties that influence modified release dosage solids -- Dosage forms of modified release oral solids -- Counseling patients -- Selected reading -- 14 Rectal and vaginal drug delivery -- Introduction -- Characteristics of the rectal route -- Drug properties and the rectal route -- Characteristics of the vaginal route -- Drug properties and the vaginal route -- Dosage forms for the rectal and vaginal routes -- Quality evaluation and assurance -- Counseling patients -- Selected reading -- 15 Nasal drug delivery -- Introduction -- Characteristics of the nasal route -- Drug properties and the nasal route -- Dosage forms for the nasal route -- Counseling patients -- Selected reading -- 16 Drug delivery to the lung and from the lung -- Introduction -- Characteristics of the respiratory route -- Drug properties and the respiratory route -- Dosage forms for the respiratory route -- Counseling patients -- Selected reading -- 17 Drug delivery to the skin -- Introduction -- Characteristics of the dermal route -- Drug properties and the dermal route -- Dosage forms for the dermal route -- Counseling patients -- Selected reading -- 18 Transdermal dosage forms: Drug delivery to the blood stream -- Introduction -- Characteristics of the transdermal route -- Drug properties and the transdermal route -- Dosage forms for the transdermal route -- Counseling healthcare providers and patients -- Selected reading -- Appendix -- References -- Answers to questions and cases -- Chapter 1 -- Chapter 2 -- Chapter 3 -- Chapter 4 -- Chapter 5 -- Chapter 6 -- Chapter 7 -- Chapter 8 -- Chapter 9 -- Chapter 10 -- Chapter 11 -- Chapter 12 -- Chapter 13 -- Chapter 14 -- Chapter 15 -- Chapter 16 -- Chapter 17 -- Chapter 18 -- Index Summary Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy course. As well as offering a summary of key information in pharmaceutics, it offers numerous case studies and MCQs for self assessment Bibliography Includes bibliographical references and index Notes Print version record Subject Drugs -- Dosage forms. Drugs -- Handbooks, manuals, etc Pharmacology -- Handbooks, manuals, etc Pharmacy -- Practice -- Handbooks, manuals, etc Chemotherapy. Pharmaceutical chemistry. Drugs. Drug Therapy Chemistry, Pharmaceutical Pharmaceutical Preparations Dosage Forms MEDICAL -- Pharmacology. Pharmaceutical chemistry Chemotherapy Drugs Drugs -- Dosage forms Pharmacology Pharmacy -- Practice Genre/Form Handbooks and manuals Form Electronic book LC no. 2014451351 ISBN 9780857111586 0857111582 9781322108537 1322108536

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