Title Long non-coding RNA : the dark side of the genome / Antonin Morillon ; RNA set coordinated by Marie-Christine Maurel

Published London : ISTE Press : Elsevier, 2018

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Description 1 online resource : color illustrations Series RNA set RNA set Contents Foreword: The modern RNA world -- Preface -- 1. Non-coding RNA, its history and discovery timeline -- 2. Definition and families of long non-coding RNA -- 3. Biological functions of long non-coding RNA -- 4. Non-coding RNA in development -- 5. Long non-coding RNA and cancer -- Concluding perspectives -- Bibliography -- Glossary -- List of acronyms -- Index Summary The dark side of the genome represents vast domains of the genome that are not encoding for proteins - the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNAIt presents the broad functional diversities of those moleculesIt presents pioneer works from the fieldProvides a comprehensive review of the field Presents fundamental and therapeutic interests Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (EBSCO, viewed February 5, 2018) Subject Non-coding RNA. RNA, Long Noncoding RNA, Untranslated SCIENCE -- Life Sciences -- Biochemistry. Non-coding RNA Form Electronic book Author Maurel, Marie-Christine ISBN 9780081023556 0081023553

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