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Title Non-protein coding RNAs / Nils G. Walter, Sarah A. Woodson, Robert T. Batey, editors
Published Berlin : Springer, [2009]
©2009
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Description 1 online resource (xi, 398 pages) : illustrations (some color)
Series Springer series in biophysics ; 13
Springer series in biophysics ; 13
Contents RNA 3D Structural Motifs: Definition, Identification, Annotation, and Database Searching; Theory of RNA Folding: From Hairpins to Ribozymes; Thermodynamics and Kinetics of RNA Unfolding and Refolding; Ribozyme Catalysis of Phosphodiester Bond Isomerization: The Hammerhead RNA and Its Relatives; The Small Ribozymes: Common and Diverse Features Observed Through the FRET Lens; Structure and Mechanism of the glmS Ribozyme; Group I Ribozymes as a Paradigm for RNA Folding and Evolution; Group II Introns and Their Protein Collaborators
Summary This book assembles chapters from experts in the Biophysics of RNA to provide a broadly accessible snapshot of the current status of this rapidly expanding field. The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. Because non-protein coding RNAs outnumber protein coding genes in mammals and other higher eukaryotes, it is now thought that the complexity of organisms is correlated with the fraction of their genome that encodes non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic transposons, higher-level organization of eukaryotic chromosomes, and gene expression itself are found to largely be directed by non-protein coding RNAs. The biophysical study of these RNAs employs X-ray crystallography, NMR, ensemble and single molecule fluorescence spectroscopy, optical tweezers, cryo-electron microscopy, and other quantitative tools. This emerging field has begun to unravel the molecular underpinnings of how RNAs fulfill their multitude of roles in sustaining cellular life. The physical and chemical understanding of RNA biology that results from biophysical studies is critical to our ability to harness RNAs for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry
Bibliography Includes bibliographical references and index
Subject Non-coding RNA.
RNA-protein interactions.
RNA, Untranslated -- metabolism.
Protein Interaction Mapping.
Proteins -- metabolism.
Form Electronic book
Author Walter, Nils G.
Woodson, Sarah A.
Batey, Robert T.
ISBN 9783540708407
3540708405
(hbk.)
(hbk.)