Front Cover; Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine; Copyright; Contents; Contributors; Part I: Introduction; Chapter 1: Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine; 1.1 Introduction; 1.1.1 Role of the Cellular Microenvironment; 1.1.2 Current Challenges; 1.2 The Cellular Microenvironment: Key Aspects; 1.2.1 What is the Microenvironment?; 1.2.2 Components of the Microenvironment; 1.2.2.1 Cells; 1.2.2.2 Soluble Signaling Molecules; 1.2.2.3 Extracellular Matrix
Biochemical Properties of ECM: Molecular Structure and CompositionBiochemical Properties of ECM: Cell-ECM Interactions; Physical Properties of ECM; 1.3 Recapitulation of Cellular Microenvironments With Bioinstructive Scaffolds; 1.3.1 Natural Versus Synthetic Biomaterials; 1.3.2 Engineering Biochemical Properties; 1.3.2.1 Adhesion Ligands; 1.3.2.2 Growth Factors and Cytokines; 1.3.3 Engineering Physical Properties; 1.3.3.1 Mechanics; 1.3.3.2 Anisotropy; 1.3.3.3 Porosity; 1.3.3.4 Topography; 1.3.4 Summary; 1.4 Cellular Detection of the Microenvironment; 1.4.1 Biochemical Signals
1.4.2 Biophysical Signals1.4.2.1 Mechanotransduction; Role of Focal Adhesions; Role of Adherens Junctions; Integrative Pathways of Focal Adhesions and Adherens Junctions; 1.5 Responding to the Microenvironment; 1.6 Conclusion; References; Chapter 2: Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffolds; 2.1 Adhesion Molecules; 2.1.1 Adhesion Receptors; 2.1.2 Adhesion Receptor-Binding Peptides; 2.2 Methods of Identifying Cell-Binding Peptides; 2.3 Peptides in Tissue Engineering; 2.3.1 Self-Assembled Peptide Scaffolds; 2.3.2 Cell-Binding Peptides; 2.3.2.1 RGD
2.3.2.2 GFOGER2.3.2.3 REDV; 2.3.2.4 KLPGWSG; 2.3.2.5 DHLSDNYTLDHDRAIH; 2.3.2.6 Summary; 2.4 Conclusion; Acknowledgments; References; Part II: Bone; Chapter 3: Bio-Instructive Scaffolds for Bone Regeneration; 3.1 Introduction; 3.2 Commonly Used Linear Polymers in Bone Tissue Engineering; 3.2.1 Natural Materials; 3.2.1.1 Protein-Based Biomaterials; 3.2.1.2 Polysaccharides-Based Biomaterials; 3.2.2 Synthetic Polymers; 3.2.2.1 Aliphatic Polyesters; 3.2.2.2 Polyalcohols; 3.2.2.3 Other Polyesters; 3.2.2.4 Poly(Amino Acids); 3.2.2.5 Other Linear Polymers; 3.2.3 Hybrid Materials
3.3 Interactions Between Materials and Cells3.3.1 The Effect of Material Morphology on Cells: Geometry Sensing of the Surrounding Network; 3.3.1.1 Porous Scaffolds; 3.3.1.2 Hydrogels; 3.3.1.3 Electrospun Fibers; 3.3.1.4 Pattern; 3.3.2 Other Factors; 3.4 Bioactive Modification of Linear Polymers for Bone Regeneration; 3.4.1 Delivery of Bioactive Substances; 3.4.2 Surface Modification; 3.5 Concluding Remarks; Acknowledgments; References; Part III: Tendon/Ligament; Chapter 4: Bio-Instructive Scaffolds for Tendon/Ligament Regeneration; 4.1 Introduction
