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Book Cover

Title Cardiovascular regenerative medicine : tissue engineering and clinical applications / editors, Vahid Serpooshan and Sean M. Wu
Published Cham, Switzerland : Springer, [2019]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (xv, 233 pages) : illustrations
Contents Intro; Cardiovascular Regenerative Medicine: An Introduction; Contents; Contributors; 1: Tissue-Engineered Stem Cell Models of Cardiovascular Diseases; Introduction; Enabling Technology: Induced Pluripotent Stem Cells; Cardiac Disease Models; Differentiation Protocols; Design Strategies for Engineered Heart Tissue; Hydrogel-Based Engineered Heart Tissues; Fibrous Scaffolds; Engineered Heart Tissue Self-Assembly; Molecular Maturity of Cardiovascular Stem Cell Models; Disease Models of Genetic Cardiac Disorders; Vascular Disease Models; Discussion of Vascular Differentiation Protocols
3: Decellularized Extracellular Matrix-Based Cardiovascular Tissue EngineeringIntroduction; Methods for Decellularization; Decellularization and Characterization of Myocardium and Pericardium; Decellularization of Cardiac Valves; Decellularization of Blood Vessels; Other Decellularization Strategies; Characterization of Decellularized Extracellular Matrix; Crosslinking and Sterilization of Decellularized Extracellular Matrix; Decellularized Extracellular Matrix Formats; Culture Coating; Injectable Materials; Patch; Whole Organ Decellularization; Bioink; Cardiac Applications
Derivation of Endothelial Cells (ECs) from hiPSCsDerivation of Vascular Smooth Muscle Cells (VSMCs) from hiPSCs; Tissue-Engineered Models for Vascular Diseases; Summary; Works Cited; 2: Phenotypic Screening of iPSC-Derived Cardiomyocytes for Cardiotoxicity Testing and Therapeutic Target Discovery; Introduction; Addressing Immaturity: How Mature Is Mature Enough?; iPSC-Derived Cardiomyocytes for Disease Modeling and Drug Discovery; iPSC-Derived Cardiomyocytes to Assess Cardiotoxicity; Conclusions and Future Perspectives; References
Myocardial Application of Cardiac-Derived MatricesMyocardial Application of Noncardiac-Derived Matrices; Myocardial Application of Hybrid Scaffolds; Repair of Cardiac Valves and Blood Vessels; Decellularized Extracellular Matrix in Preclinical and Clinical Trials; Future Outlook; References; 4: 3D Bioprinting of Cardiovascular Tissue Constructs: Cardiac Bioinks; Introduction; Types of Bioinks; Cardiac Bioink Characteristics; Outlook and Conclusions; References; 5: Nanobiomaterial Advances in Cardiovascular Tissue Engineering; Introduction; Advances in Nanobiotechnology
The Heart at the NanoscaleEngineering Nanotopography of Cardiac Tissue Scaffolds; Nanofibrous Scaffolds; Surface Nanostructures; Molecular and Cellular Imprinting; Conductive Nanomaterials; Spherical Conductive Nanomaterials; High-Aspect Ratio Conductive Nanomaterials; Engineering Nanocarriers for Cardiac Tissue Repair; Future Outlook; References; 6: Bioengineering 3D Cardiac Microtissues Using Bioassembly; Introduction; Bioassembly Techniques for 3D Cardiac Microtissues; Acoustic Field-Guided Assembly; Faraday Wave; Surface Acoustic Wave; Magnetic Field-Guided Assembly
Summary This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed July 05, 2019)
Subject Cardiovascular system -- Diseases -- Treatment
Regenerative medicine
Tissue engineering
Cardiovascular system -- Diseases -- Treatment.
Regenerative medicine.
Tissue engineering.
Form Electronic book
Author Serpooshan, Vahid, editor
Wu, Sean M., editor
ISBN 3030200477