Title Recent advances in retinal degeneration / Robert E. Anderson, Matthew M. LaVail and Joe G. Hollyfield, editors

Published New York, N.Y. : Springer, ©2008

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Description 1 online resource (xxxiv, 423 pages) : illustrations (some color), portrait Series Advances in experimental medicine and biology ; v. 613 Advances in experimental medicine and biology ; v. 613. Contents Part I: Keynote lectures -- Curing blindness with stem cells: hope, reality, and challenges / Ruben Adler -- Retinal degenerations: planning for the future / Eliot L. Berson -- Part II: Neuroprotection -- Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1 / Nicolas G. Bazan -- On the role of CNTF as a potential therapy for retinal degeneration: Dr. Jekyll or Mr. Hyde? / William A. Beltran -- Nanoceria particles prevent ROI-induced blindness / Junping Chen [and others] -- An in-vivo assay to identify compounds protective against light induced apoptosis / Yogita Kanan [and others] -- Role of BCL-XL in photoreceptor survival / Yun-Zheng Le [and others] -- The hypoxic transcriptome of the retina: identification of factors with potential neuroprotective activity / Markus Thiersch [and others] -- Part III: Gene therapy and neuroprotection -- Lentiviral gene transfer-mediated cone vision restoration in RPE65 knockout mice / Alexis-Pierre Bemelmans [and others] -- In vitro analysis of ribozyme-mediated knockdown of an ADRP associated rhodopsin mutation / Dibyendu Chakraborty [and others] -- Gene therapy for mouse models of ADRP / Marina S. Gorbatyuk, William W. Hauswirth, and Alfred S. Lewin -- Development of viral vectors with optimal transgene expression for ocular gene therapies / Takao Hashimoto -- Adeno-associated viral vectors and the retina / John J. Alexander and William W. Hauswirth -- Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa / May Nour, Steven J. Fliesler, and Muna I. Naash -- Morphological aspects related to long-term functional improvement of the retina in the 4 years following rAAV-mediated gene transfer in the RPE65 null mutation dog / Kristina Narfström [and others] -- Virus-mediated gene delivery to neuronal progenitors / Tonia S. Rex -- Part IV: Animal models of retinal degeneration -- Loss of visual and retinal function in light-stressed mice / Drew Everhart [and others] -- ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration / Goldis Malek [and others] -- Oxygen supply and retinal function: insights from a transgenic animal model / Edda Fahl [and others] -- Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray / Gerardo L. Paez [and others] -- Toward a higher fidelity model of AMD / Brian J. Raisler [and others] -- The potential of ambient light restriction to restore function to the degenerating P23H-3 rat retina / Krisztina Valter, Diana K. Kirk, and Jonathan Stone Summary Retinal Degenerations is the result of The International Symposium on Retinal Degeneration which has become perhaps the most important research meeting in the field. The topics in this volume explore the etiology, cellular mechanisms, epidemiology, generics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an Notes "XII International Symposium on Retinal Degeneration (also known as RD2006) held October 23-28, 2006 in San Carlos de Bariloche, Argentina"--Preface Bibliography Includes bibliographical references and index Notes Print version record In Springer eBooks Subject Retinal degeneration -- Congresses Diseases -- Animal models. Gene therapy. Retinal degeneration. Retinal Degeneration -- genetics Disease Models, Animal Genetic Therapy Photoreceptors Retinal Degeneration -- physiopathology Retinal Degeneration -- therapy Retinal Degeneration MEDICAL -- Ophthalmology. HEALTH & FITNESS -- Vision. Retinal Degeneration -- genetics. Disease Models, Animal. Gene therapy. Photoreceptors. Retinal Degeneration -- physiopathology. Retinal Degeneration -- therapy. Retinal degeneration. Gene therapy Diseases -- Animal models Retinal degeneration Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Anderson, Robert E. (Robert Eugene) LaVail, Matthew M. Hollyfield, Joe G. ISBN 9780387749020 0387749020 9780387749044 0387749047 6611137777 9786611137779

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