A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES)
A genus of RETROVIRIDAE comprising endogenous sequences in mammals, related RETICULOENDOTHELIOSIS VIRUSES, AVIAN, and a reptilian virus. Many species contain oncogenes and cause leukemias and sarcomas
As a geographic subdivision, this heading is used directly. Headings for entities located within the Gaza Strip are used indirectly through Gaza Strip as geographic subdivisions
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
Rett syndrome -- Popular works. : Understanding Rett syndrome : a practical guide for parents, teachers, and therapists / Barbro Lindberg ; foreword by Andreas Rett
1991
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Rett syndrome -- Study and teaching. : Understanding Rett syndrome : a practical guide for parents, teachers, and therapists / Barbro Lindberg ; foreword by Andreas Rett
1991
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Rett Syndrome -- therapy. : Understanding Rett syndrome : a practical guide for parents, teachers, and therapists / Barbro Lindberg ; foreword by Andreas Rett
Retta Dixon Children's Home -- History. / http://id.loc.gov/authorities/names/n91041080 http://id.loc.gov/authorities/subjects/sh99005024 : Take this child : from Kahlin Compound to the Retta Dixon Children's Home / Barbara Cummings